Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties
| Autor: | Anton Vonk-Noordegraaf, Nico Westerhof, Theo J.C. Faes, Taco Kind |
|---|---|
| Přispěvatelé: | Pulmonary medicine, Physics and medical technology, Physiology, ICaR - Ischemia and repair |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Biomedical Engineering Diastole 030204 cardiovascular system & hematology Proportional pressure Article 03 medical and health sciences 0302 clinical medicine medicine.artery Internal medicine Heart rate medicine Pressure In patient business.industry Elastance model medicine.disease Control subjects Pulmonary hypertension Three-element windkessel model Compliance (physiology) Pulmonary artery medicine.anatomical_structure 030228 respiratory system Vascular resistance Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Kind, T, Faes, T J C, Vonk Noordegraaf, A & Westerhof, N 2011, ' Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties ', Cardiovascular Engineering and Technology, vol. 2, no. 1, pp. 15-23 . https://doi.org/10.1007/s13239-010-0027-1 Cardiovascular Engineering and Technology Cardiovascular Engineering and Technology, 2(1), 15-23. Springer Publishing Company |
| ISSN: | 1869-408X |
| DOI: | 10.1007/s13239-010-0027-1 |
| Popis: | Recently, it was shown that proportional relationships exist between systolic, diastolic and mean pulmonary artery pressure (P(sys), P(dia) and P(mean)) and that they are maintained under various conditions in both health and disease. An arterial-ventricular interaction model was used to study the contribution of model parameters to the ratios P(sys)/P(mean), and P(dia)/P(mean). The heart was modeled by a time-varying elastance function, and the arterial system by a three-element windkessel model consisting of peripheral resistance, R(p), arterial compliance C(a), and pulmonary artery characteristic impedance Z(0). Baseline model parameters were estimated in control subjects and compared to values estimated in patients with pulmonary hypertension. Results indicate that experimentally derived ratios P(sys)/P(mean) and P(dia)/P(mean) could be accurately reproduced using our model (1.59 and 0.61 vs. 1.55 and 0.64, respectively). Sensitivity analysis showed that the (empirical) constancy of P(sys)/P(mean) and P(dia)/P(mean) was primarily based on the inverse hyperbolic relation between total vascular resistance (R(T); calculated as R(p) + Z(0)) and C(a), (i.e. constant R(T)C(a) product). Of the cardiac parameters, only heart rate affected the pressure ratios, but the contribution was small. Therefore, we conclude that proportional relations between systolic, diastolic and mean pulmonary artery pressure result from the constancy of R(T)C(a) thus from pulmonary arterial properties, with only little influence of heart rate. |
| Databáze: | OpenAIRE |
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