Blood–Brain Barrier Compromise Does Not Predict Perihematoma Edema Growth in Intracerebral Hemorrhage
| Autor: | Derek Emery, Kenneth Butcher, Bronwen Gould, Mahesh Kate, Thomas Jeerakathil, Jayme C. Kosior, Andrew M. Demchuk, S B Coutts, Negar Asdaghi, Rebecca McCourt, Michael D. Hill |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Randomization Contrast Media Blood Pressure Brain Edema Perfusion scanning Permeability Hematoma Interquartile range Edema Hematoma Subdural Intracranial Humans Medicine Aged Cerebral Hemorrhage Aged 80 and over Advanced and Specialized Nursing Intracerebral hemorrhage business.industry Middle Aged Prognosis medicine.disease Radiography Blood pressure Blood-Brain Barrier Cerebrovascular Circulation Anesthesia Disease Progression Female Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Stroke. 46:954-960 |
| ISSN: | 1524-4628 0039-2499 0096-3976 |
| DOI: | 10.1161/strokeaha.114.007544 |
| Popis: | Background and Purpose— There are limited data on the extent of blood–brain barrier (BBB) compromise in acute intracerebral hemorrhage patients. We tested the hypotheses that BBB compromise measured with permeability-surface area product (PS) is increased in the perihematoma region and predicts perihematoma edema growth in acute intracerebral hemorrhage patients. Methods— Patients were randomized within 24 hours of symptom onset to a systolic blood pressure (SBP) treatment of Results— Patients were randomized at a median (interquartile range) time of 9.3 hours (14.1) from symptom onset. Treatment groups were balanced with respect to baseline SBP and hematoma volume. Perihematoma PS (5.1±2.4 mL/100 mL per minute) was higher than PS in contralateral regions (3.6±1.7 mL/100 mL per minute; P P P =0.51). Conclusions— BBB permeability is focally increased in the hematoma and perihematoma regions of acute intracerebral hemorrhage patients. BBB compromise does not predict acute perihematoma edema volume or edema growth. SBP reduction does not affect BBB permeability. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00963976. |
| Databáze: | OpenAIRE |
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