Intestinal anti-inflammatory activity of the total alkaloid fraction from Fumaria capreolata in the DSS model of colitis in mice
| Autor: | Teresa Vezza, Francesca Algieri, Alba Rodríguez-Nogales, Julio Gálvez, Noureddine Bribi, José Garrido-Mesa, María Elena Rodríguez-Cabezas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.drug_class
Clinical Biochemistry Anti-Inflammatory Agents Pharmaceutical Science Inflammation Pharmacology 01 natural sciences Biochemistry Inflammatory bowel disease Anti-inflammatory Mice Alkaloids In vivo Drug Discovery medicine Animals Humans Colitis Molecular Biology biology Plant Extracts 010405 organic chemistry Chemistry Fumaria Macrophages Alkaloid Dextran Sulfate fungi Organic Chemistry respiratory system Inflammatory Bowel Diseases medicine.disease biology.organism_classification 0104 chemical sciences Intestines Disease Models Animal 010404 medicinal & biomolecular chemistry Gene Expression Regulation Fumaria capreolata Molecular Medicine Inflammation Mediators medicine.symptom |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 30:127414 |
| ISSN: | 0960-894X |
| Popis: | Fumaria genus has been traditionally used for managing inflammatory and gastrointestinal disorders. The study evaluates the immunomodulatory potential of the total alkaloid fraction from Fumaria capreolata L. (AFC) in primary macrophages and the intestinal anti-inflammatory effect in a dextran sodium sulphate-induced colitis in mice. AFC inhibited LPS-stimulated bone marrow-derived macrophages gene expression program dose-dependently. In vivo, AFC markedly reduced macroscopic and microscopic signs of intestinal inflammation. Besides, it restored the colonic expression of pro-inflammatory and anti-inflammatory mediators, as well as enhanced the expression of intestinal barrier markers. These results demonstrate the potential of AFC extract as a therapeutic tool for the management of inflammatory bowel disease. |
| Databáze: | OpenAIRE |
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