Secretory meningioma with KLF4 K409Q mutation in collision with glioma
| Autor: | Juan Ruiz, Teresa Hernández, Juan F Díaz, Manuela Mollejo, Jesus Andrade, Elena Capilla, Bárbara Meléndez, Juan Antonio Martín Ruiz |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_treatment
Kruppel-Like Transcription Factors Glial tumor Pathology and Forensic Medicine Meningioma Kruppel-Like Factor 4 Young Adult Glioma Meningeal Neoplasms medicine Humans neoplasms Aged 80 and over medicine.diagnostic_test Brain Neoplasms business.industry Magnetic resonance imaging General Medicine medicine.disease Immunohistochemistry nervous system diseases Radiation therapy Neurology Mutation Cancer research Female Neurology (clinical) Glioblastoma business Secretory Meningioma Anaplastic astrocytoma |
| Zdroj: | Clinical Neuropathology. 34:322-329 |
| ISSN: | 0722-5091 |
| DOI: | 10.5414/np300860 |
| Popis: | Aims The simultaneous occurrence of two primary intracranial tumors is a rare event, especially if unrelated to radiotherapy or genetic disorders. We present two patients, both with two primary intracranial tumors simultaneously present at adjacent sites, in order to explore a possible mechanism of synchronous tumor formation. Methods We performed a molecular analysis of the K409Q mutation of the KLF4 gene, in addition to conventional immunohistochemistry. Results Preoperative gadolinium-enhanced magnetic resonance imaging revealed a necrotic mass with an irregular ring-like enhancement adjacent to a frontal meningioma in patient 1, and an infiltrative non-enhancing glial tumor with no evidence of another tumor in patient 2. Postoperative histological examination revealed the presence of two distinct tumors in both cases: secretory meningioma and glioblastoma in patient 1 and secretory meningioma and anaplastic astrocytoma in patient 2. Secretory meningiomas both showed the KLF4 K409Q mutation, while none of the glial tumors had it. Conclusions To our knowledge, these are the first two cases reported of the simultaneous occurrence of secretory meningiomas with mutation of KLF4 in collision with a glioblastoma and an anaplastic astrocytoma, respectively. These collision tumors presumably have different molecular origins. |
| Databáze: | OpenAIRE |
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