The impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populations
| Autor: | Seiko Kato, Karina Tozatto-Maio, Arnon Nagler, Jorge Sierra, Yoshiko Atsuta, Takahiro Fukuda, Junya Kanda, Takanori Ohta, Emanuele Angelucci, Eliane Gluckman, Takafumi Kimura, Riccardo Saccardi, Masatsugu Tanaka, Hiromi Hayashi, Tatsuo Ichinohe, Satoshi Takahashi, Fumihiko Kimura, Naoyuki Uchida, Shinichi Kako, Fernanda Volt, Mohamad Mohty, Masamitsu Yanada, Guillermo Sanz, Vanderson Rocha, Annalisa Ruggeri, Shinichiro Okamoto, Edouard Forcade |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
UNRELATED DONOR medicine.medical_specialty Transplantation Conditioning Multivariate analysis Epidemiology Graft vs Host Disease Japan immune system diseases Internal medicine VERSUS-HOST-DISEASE Humans Medicine ACUTE-LEUKEMIA Cord blood transplantation Transplantation Acute leukemia Adult patients business.industry MORTALITY Hazard ratio GRAFT Hematopoietic Stem Cell Transplantation STEM-CELL TRANSPLANTATION Hematology HLA Leukemia Myeloid Acute surgical procedures operative Risk factors Cohort RISK-FACTORS SURVIVAL Disease risk Chronic gvhd Cord Blood Stem Cell Transplantation business SIBLING BONE-MARROW |
| Zdroj: | BONE MARROW TRANSPLANTATION r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | The impact of GVHD and graft-versus-leukemia effect in unrelated cord blood transplantation (UCBT) is controversial. In the Eurocord/ALWP EBMT and JSTCT/JDCHCT collaborative study, we evaluated the impact of GVHD on UCBT outcomes in Japanese and European registries. A total of 3, 690 adult patients with acute leukemia who received their first single UCBT were included. A multivariate analysis of overall survival (OS) revealed a positive impact of grade II acute GVHD compared with grade 0-I GVHD, in the Japanese cohort (hazard ratio (HR), 0.81; P = 0.001), and an adverse impact in the European cohort (HR, 1.37; P = 0.007). A negative impact of grade III-IV acute GVHD on OS was observed regardless of registries. In the analysis of relapse, a positive impact of grade II acutes GVHD compared with grade 0–I GVHD was observed only in the Japanese cohort, regardless of disease risk. The positive impact of limited chronic GVHD on OS was observed only in the Japanese cohort. In conclusion, a positive impact of mild GVHD after a single UCBT was observed only in the Japanese cohort. This could explain the ethnic difference in UCBT outcomes and might contribute to the preference usage of UCBT in Japan. 急性白血病治療における臍帯血移植後の合併症が及ぼす予後への影響 --国際共同研究から明らかになった日欧での違い--. 京都大学プレスリリース. 2021-10-19. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink