| Autor: |
Raeda, Mubariki, Zahava, Vadasz |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Autoimmunity Reviews. 21:103116 |
| ISSN: |
1568-9972 |
| DOI: |
10.1016/j.autrev.2022.103116 |
| Popis: |
B cells are major players in immune responses being the source of protective antibodies and antigen presenting cells. When self-tolerance fails, auto reactive B cells produce autoantibodies and pro-inflammatory cytokines leading to the development of autoimmune diseases. Many recent studies have assessed importance of metabolic pathways in B cells, demonstrating their role in controlling autoimmunity and maintaining immune homeostasis. Alterations in B cell functions in autoimmune diseases are closely associated with abnormal metabolic shifts, allowing auto reactive B cells to escape tolerogenic checkpoints. Understanding the metabolic changes in B cells, opens up new possibilities for targeting metabolic pathways and manipulating metabolic avenues as a therapeutic strategy for the treatment of autoimmune diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect