Porcine vs bovine surfactant therapy for preterm neonates with RDS: systematic review with biological plausibility and pragmatic meta-analysis of respiratory outcomes
| Autor: | Ascanio Tridente, Daniele De Luca, Lucia De Martino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Swine Review Surfactant therapy 03 medical and health sciences 0302 clinical medicine Neonate Internal medicine Surfactant Pragmatic Clinical Trials as Topic Medicine Animals Humans Respiratory system RDS Lung haemorrhage lcsh:RC705-779 Respiratory Distress Syndrome Newborn Respiratory distress business.industry Infant Newborn Pulmonary Surfactants lcsh:Diseases of the respiratory system 030104 developmental biology Systematic review 030228 respiratory system Meta-analysis Gestation Cattle Biological plausibility Therapy business Infant Premature |
| Zdroj: | Respiratory Research Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019) |
| ISSN: | 1465-993X 1465-9921 |
| Popis: | Background Bovine surfactants are known to be clinically equivalent but it is unclear if porcine or bovine surfactants at their licensed dose should be preferred to treat respiratory distress syndrome in preterm neonates. Methods We performed a comprehensive review of biochemical and pharmacological features of surfactants to understand the biological plausibility of any clinical effect. We then performed a pragmatic meta-analysis comparing internationally marketed porcine and bovine surfactants for mortality and respiratory outcomes. Search for randomised controlled trials with no language/year restrictions and excluding “grey” literature, unpublished or non-peer reviewed reports was conducted, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the most recent methodological recommendations. Results Sixteen articles were included in the review and 14 in the meta-analysis (1491 neonates). 200 mg/kg poractant-α (a porcine surfactant) was associated with lower BPD/mortality (OR 0.632[95%CI:0.494, 0.809];p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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