Sub-chronic toxicity study of ethanol stem-bark extract of Blighia sapida (Sapindaceae) in wistar rats
| Autor: | J.O. Areola, F.T. Asaolu, S.G. Ogunleye, M.B. Adekola, O.O. Babalola, Apalowo Oe, N. O. Omisore |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Dose-response relationship Sapindaceae Toxicology Biochemistry Natural product 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine lcsh:Social sciences (General) lcsh:Science (General) Stem bark Multidisciplinary Ethanol biology Traditional medicine business.industry Hematology Blighia biology.organism_classification Bioaccumulation Acute toxicity Subchronic toxicity Dose–response relationship 030104 developmental biology chemistry Toxicity lcsh:H1-99 business 030217 neurology & neurosurgery lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 6, Iss 2, Pp e02801-(2020) |
| ISSN: | 2405-8440 |
| Popis: | Blighia sapida has been used in the treatment of different pathologies. The study aimed at evaluating the acute and sub-chronic toxicity of ethanol stem-bark extract of B. sapida. The acute toxicity was evaluated by gavage administration at single dose and the extract was also administered at doses of 250, 500 and 750 mg/kg body weight every other day for ninety day. No mortality or observable signs of toxicity were observed for acute and sub-chronic effects of the extract on the tested animals. No significant difference (P > 0.05) in haematological and biochemical parameters compared to the control group. However, histopathological observation revealed some derangements which could be due to continuous consumption of the extract by the animals. It implied that care must be exercised in the use of the plant for a long period of time to prevent its possible long-term toxic effects. |
| Databáze: | OpenAIRE |
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