Switching from calcium carbonate to sevelamer hydrochloride has suppressive effects on the progression of aortic calcification in hemodialysis patients: assessment using plain chest X-ray films

Autor:	Takashi Miyamoto, Satoshi Yamamoto, Mai Oue, Takeshi Nakanishi, Kahori Hori, Masaaki Izumi, Yoshihiko Nishian, Hiroomi Kasumoto, Syunpei Morita, Rie Kitamura
Rok vydání:	2008
Předmět:	Nephrology Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Urology Aortic Diseases chemistry.chemical_element Sevelamer Calcium Critical Care and Intensive Care Medicine Calcium Carbonate chemistry.chemical_compound Renal Dialysis medicine.artery Internal medicine medicine Polyamines Humans Aged Chelating Agents Retrospective Studies Aorta business.industry Calcinosis General Medicine Middle Aged medicine.disease Surgery Phosphate binder Calcium carbonate chemistry Disease Progression Kidney Failure Chronic Female Radiography Thoracic Hemodialysis Antacids business Calcification medicine.drug
Zdroj:	Renal failure. 30(10)
ISSN:	1525-6049
Popis:	Sevelamer hydrochloride, a non-aluminum- and non-calcium-containing hydrogel, is an effective phosphate binder in dialysis patients. The suppressive effect of the switching from calcium carbonate to sevelamer hydrochloride on the progression of vascular calcification was examined by measuring areas of calcification on routine chest X-rays using image-analyzing software. The data of 69 maintenance hemodialysis patients were analyzed retrospectively. Over a period of 18 months, 19 patients took only sevelamer hydrochloride as a phosphate binder, while the other 50 patients took only calcium carbonate. The area of calcification increased in the calcium carbonate group, but did not change significantly in the sevelamer group. While the usefulness of computed tomography in detecting vascular calcification in hemodialysis patients has been reported previously, the suppressive effects of switching from calcium carbonate to sevelamer hydrochloride on the progression of aortic calcification can be observed without computed tomography by using the plain chest X-ray films that are routinely performed in hemodialysis clinics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf92f530a782542f620f7731b2d4cd6 https://pubmed.ncbi.nlm.nih.gov/19016145 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.