Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance
| Autor: | Stacey N Keenan, Matthew J. Watt, Magdalene K. Montgomery |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Mitochondrial Diseases Endocrinology Diabetes and Metabolism Golgi Apparatus 030209 endocrinology & metabolism Cell Communication Mitochondrion Endoplasmic Reticulum 03 medical and health sciences symbols.namesake 0302 clinical medicine Insulin resistance Lipid droplet Organelle Peroxisomes Internal Medicine Humans Medicine Inner mitochondrial membrane Organelles business.industry Endoplasmic reticulum Cell Membrane Lipid Droplets Overweight Golgi apparatus medicine.disease Mitochondria Cell biology 030104 developmental biology Diabetes Mellitus Type 2 Lipotoxicity symbols Insulin Resistance Lysosomes business |
| Zdroj: | Current Diabetes Reports. 20 |
| ISSN: | 1539-0829 1534-4827 |
| Popis: | Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been disputed for decades. This review aims to briefly summarize the current knowledge on mitochondrial dysfunction in metabolic tissues and to particularly focus on addressing a new perspective of mitochondrial dysfunction, the altered capacity of mitochondria to communicate with other organelles within insulin-resistant tissues. Organelle interactions are temporally and spatially formed connections essential for normal cell function. Recent studies have shown that mitochondria interact with various cellular organelles, such as the endoplasmic reticulum, lysosomes and lipid droplets, forming inter-organelle junctions. We will discuss the current knowledge on alterations in these mitochondria-organelle interactions in insulin resistance and diabetes, with a focus on changes in mitochondria-lipid droplet communication as a major player in ectopic lipid accumulation, lipotoxicity and insulin resistance. |
| Databáze: | OpenAIRE |
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