Effects of antiviral drug therapy on dynamic thiol/disulphide homeostasis and nitric oxide levels in COVID-19 patients
| Autor: | Seniz Demiryürek, Abdullah T. Demiryürek, Özgür Altınbaş, Ahmet Saracaloglu, Kübra Koçak, Ayşe Özlem Mete |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.drug_class Pharmacology Antiviral therapy medicine.disease_cause Antiviral Agents Article Nitric oxide Pathogenesis chemistry.chemical_compound Disulfide Pharmacotherapy medicine Homeostasis Humans Disulfides Sulfhydryl Compounds Aged chemistry.chemical_classification Chemistry SARS-CoV-2 COVID-19 Venous blood Middle Aged COVID-19 Drug Treatment Thiol Female Antiviral drug Oxidative stress |
| Zdroj: | European Journal of Pharmacology |
| ISSN: | 1879-0712 0014-2999 |
| Popis: | The novel coronavirus disease 2019 (COVID-19) has led to a serious global pandemic. Although an oxidative stress imbalance occurs in COVID-19 patients, the contributions of thiol/disulphide homeostasis and nitric oxide (NO) generation to the pathogenesis of COVID-19 have been poorly identified. Therefore, the aim of this study was to evaluate the effects of antiviral drug therapy on the serum dynamics of thiol/disulphide homeostasis and NO levels in COVID-19 patients. A total of 50 adult patients with COVID-19 and 43 sex-matched healthy control subjects were enrolled in this prospective study. Venous blood samples were collected immediately on admission to the hospital within 24 h after the diagnosis (pre-treatment) and at the 15th day of drug therapy (post-treatment). Serum native thiol and total thiol levels were measured, and the amounts of dynamic disulphide bonds and related ratios were calculated. The average pre-treatment total and native thiol levels were significantly lower than the post-treatment values (P |
| Databáze: | OpenAIRE |
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