Validation of the Vitiligo Noticeability Scale: a patient-reported outcome measure of vitiligo treatment success

Autor: Selina K. Tour, Adrian S W Yong, Jonathan M. Batchelor, Alan A Montgomery, Kim S Thomas, Wei Tan
Rok vydání: 2015
Předmět:
Male
Light therapy
medicine.medical_treatment
Medicine (miscellaneous)
Vitiligo
Bioinformatics
law.invention
030207 dermatology & venereal diseases
Cohen's kappa
0302 clinical medicine
Quality of life
Randomized controlled trial
law
Surveys and Questionnaires
Pharmacology (medical)
Child
Middle Aged
Treatment Outcome
Treatment success
Patient Satisfaction
Child
Preschool
Scale (social sciences)
030220 oncology & carcinogenesis
Female
Patient-reported outcome
Psychosocial
Adult
Treatment response
medicine.medical_specialty
Adolescent
Dermatology
Young Adult
03 medical and health sciences
Patient satisfaction
medicine
Humans
Patient Reported Outcome Measures
Aged
business.industry
Infant
Newborn
Infant
Construct validity
Original Articles
medicine.disease
Surgery
Anatomical sites
Poster Presentation
General Dermatology
Quality of Life
Physical therapy
business
Zdroj: The British Journal of Dermatology
Trials
ISSN: 0007-0963
1365-2133
DOI: 10.1111/bjd.14208
Popis: Summary Background Patient‐reported outcome measures are rarely used in vitiligo trials. The Vitiligo Noticeability Scale (VNS) is a new patient‐reported outcome measure assessing how ‘noticeable’ vitiligo patches are after treatment. The noticeability of vitiligo after treatment is an important indicator of treatment success from the patient's perspective. Objectives To evaluate the construct validity, acceptability and interpretability of the VNS. Methods Clinicians (n = 33) and patients with vitiligo (n = 101) examined 39 image pairs, each depicting a vitiligo lesion pre‐ and post‐treatment. Using an online questionnaire, respondents gave a global assessment of treatment success and a VNS score for treatment response. Clinicians also estimated percentage repigmentation of lesions (< 25%; 25–50%; 51–75%; > 75%). Treatment success was defined as ‘yes’ on global assessment, a VNS score of 4 or 5, and > 75% repigmentation. Agreement between respondents and the different scales was assessed using kappa (κ) statistics. Results Vitiligo Noticeability Scale scores were associated with both patient‐ and clinician‐reported global treatment success (κ = 0·54 and κ = 0·47, respectively). Percentage repigmentation showed a weaker association with patient‐ and clinician‐reported global treatment success (κ = 0·39 and κ = 0·29, respectively). VNS scores of 4 or 5 can be interpreted as representing treatment success. Images depicting post‐treatment hyperpigmentation were less likely to be rated as successful. Conclusions The VNS is a valid patient‐reported measure of vitiligo treatment success. Further validation of the VNS is required, using larger sets of clinical pre‐ and post‐treatment images, affecting a wider range of anatomical sites.
What's already known about this topic? The lack of standardized outcome measures makes comparison of vitiligo treatment efficacy difficult.Patient‐reported outcome measures are rarely used in vitiligo trials.Patient‐reported outcome measures assessing vitiligo treatment success from the patient's perspective have yet to be developed.The Vitiligo Noticeability Scale (VNS) is a new patient‐reported outcome measure of treatment response, which has been shown to have face validity. What does this study add? The VNS has good construct validity, acceptability and interpretability, supporting its inclusion as a patient‐reported measure of the cosmetic acceptability of treatment response in vitiligo trials.The VNS is a better and more consistent indicator of global treatment success than percentage repigmentation.VNS scores of 4 or 5 can be interpreted as representing treatment success.Further validation of the VNS is required. Plain language summary available online
Databáze: OpenAIRE
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