Patient-reported fatigue refines prognosis in higher-risk myelodysplastic syndromes (MDS): a MDS-CAN study
| Autor: | Lisa Chodirker, Liying Zhang, Dina Khalaf, Irina Amitai, Eve St-Hilaire, Mohamed Elemary, Versha Banerji, Robert Delage, Thomas J. Nevill, Rena Buckstein, Mary-Margaret Keating, John M. Storring, Mitchell Sabloff, Anne Parmentier, Karen W.L. Yee, Alexandre Mamedov, Michelle Geddes, Nancy Zhu, Grace Christou, Mohammed Siddiqui, Brian Leber, April Shamy, Heather A. Leitch, Nicholas Finn, Lee Mozessohn |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Canada Scoring system 03 medical and health sciences 0302 clinical medicine Rating scale Internal medicine Overall survival medicine Humans In patient Patient Reported Outcome Measures Registries Fatigue Aged Aged 80 and over business.industry Myelodysplastic syndromes Hematology Middle Aged medicine.disease Prognosis 030220 oncology & carcinogenesis Myelodysplastic Syndromes Prognostic model Disease risk Quality of Life Female business 030215 immunology |
| Zdroj: | British journal of haematologyReferences. 194(2) |
| ISSN: | 1365-2141 |
| Popis: | The incorporation of patient-reported outcomes with traditional disease risk classification was found to strengthen survival prediction in patients with myelodysplastic syndromes (MDS). In the present Canadian MDS registry analysis, we validate a recently reported prognostic model, the Fatigue-International Prognostic Scoring System among higher-risk patients [FA-IPSS(h)], which incorporates patients' reported fatigue, assessed by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life-Core 30 (QLQ-C30), with a threshold of ≥45 points, in higher IPSS score, stratifying them into distinct subgroups with different survival outcomes. We further validated this concept, using the Revised IPSS >3·5 as cut-off for the definition of higher-risk MDS, and patients' reported fatigue according to Edmonton Symptom Self-Assessment Scale (ESAS) Global Fatigue Scale (GFS), a single-item fatigue rating scale, which is easier to deploy. This emphasises the power of self-reported fatigue at refining overall survival predictions in higher-risk MDS and further bolsters the importance of considering patient-related outcomes in global assessments. |
| Databáze: | OpenAIRE |
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