The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
| Autor: | Maria Gazouli, Klio Chatzistefanou, Konstantinos Giannopoulos, Marilita M Moschos, Anthi Bakouli |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Retina Retinal Disorder Retinal pigment epithelium genetic structures business.industry Review Pathophysiology eye diseases Serous fluid medicine.anatomical_structure Central Serous Chorioretinopathy Genes Ophthalmology Diagnosis medicine Metamorphopsia Choroid medicine.symptom business Micropsia Central scotoma |
| Zdroj: | Journal of Genomics |
| ISSN: | 1839-9940 |
| Popis: | Central serous chorioretinopathy is characterized by neurosensory detachment of the central retina secondary to fluid leakage through the retinal pigment epithelium. Though it has an incidence of 9,9 per 100.000 in men and 1,7 per 100.000 in women, it is the fourth most common retinal disorder. Central serous chorioretinopathy patients present with blurred vision, central scotoma, metamorphopsia, micropsia and mild color discrimination. It is usually a self-limited disorder with nearly none or minimal visual impairment but in some patients the disease persists and may cause severe visual impairment. Central serous chorioretinopathy pathophysiology is not well understood. Choroid, retinal pigment epithelium and hormonal pathways seem to play important roles in central serous chorioretinopathy pathophysiology. Also, familial cases of the disease indicate that there is a genetic background. The identification of certain disease genes could lead to the development of better diagnostic and therapeutic approaches for central serous chorioretinopathy patients. |
| Databáze: | OpenAIRE |
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