Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

Autor:	Masato Kawakami, Asako Sugimoto, Haruhiko Fuwa, Makoto Sasaki, Tomoya Sugai, Shinsuke Niwa, Shota Yanagi, Takuma Noguchi
Rok vydání:	2019
Předmět:	Cell Survival Molecular Conformation Neopeltolide Mitochondrion 010402 general chemistry Endoplasmic Reticulum 01 natural sciences Biochemistry Fluorescence Live cell imaging Humans Tissue Distribution Physical and Theoretical Chemistry Cell Proliferation Fluorescent Dyes Dose-Response Relationship Drug 010405 organic chemistry Chemistry Endoplasmic reticulum Organic Chemistry Optical Imaging Subcellular localization 0104 chemical sciences Mitochondria A549 Cells Biophysics Macrolides
Zdroj:	Organicbiomolecular chemistry. 17(28)
ISSN:	1477-0539
Popis:	Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bebbd6515546bcbbf603f7b2e67713f https://pubmed.ncbi.nlm.nih.gov/31259993 Zobrazit plný text záznamu