Association between OPCRIT dimensions and polymorphisms of HPA axis genes in bipolar disorder
| Autor: | Andrzej Pogłodziński, Malgorzata Maciukiewicz, Joanna Hauser, Aleksandra Szczepankiewicz, Anna Leszczynska-Rodziewicz |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Receptors Vasopressin endocrine system medicine.medical_specialty Bipolar Disorder Receptors Corticotropin-Releasing Hormone AVPR1B Gene Receptors Glucocorticoid Glucocorticoid receptor Arginine Vasopressin Receptor Internal medicine medicine Humans Bipolar disorder CRHR1 Gene Gene Polymorphism Genetic Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Endocrinology Hormone receptor Female Psychology |
| Zdroj: | Journal of Affective Disorders. 151:744-747 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2013.08.012 |
| Popis: | The aim of the study was to investigate the possible association between polymorphisms of HPA axis genes-CRHR1 (corticotrophin-releasing hormone receptor), NR3C1 (glucocorticoid receptor) and AVPR1B (arginine vasopressin receptor) and dimensions of bipolar disorder assessed by OPCRIT. We examined 560 patients with diagnosis of bipolar disorder (n=457) and unipolar disorder (n=103). Diagnosis was established by SCID and OPCRIT. We found association between polymorphisms of AVPR1b gene and psychotic dimension and CRHR1 polymorphisms and excitement and psychotic dimension. Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder. |
| Databáze: | OpenAIRE |
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