The Relationship of IL-8 and IL-10 Myokines and Performance in Male Marathon Runners Presenting Exercise-Induced Bronchoconstriction
| Autor: | André Luis Lacerda Bachi, Roberta Foster, Luiz Antonio Luna Junior, Mauro Vaisberg, Maria Augusta Peduti Dal'Molim Kiss, Nabil Ghorayeb, Marino Benetti, Ana Paula Rennó Sierra, Juliana de Melo Batista dos Santos, Dominique Bullens, José Roberto Araújo, Rodolfo de Paula Vieira |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
INTERLEUKIN-8 Health Toxicology and Mutagenesis lcsh:Medicine endurance exercise Gastroenterology Running EIB FEV1 0302 clinical medicine Public Environmental & Occupational Health DAMAGE medicine.diagnostic_test CHALLENGES pulmonary function Interleukin-10 ALLERGY Interleukin 10 Bronchoconstriction medicine.symptom Life Sciences & Biomedicine Spirometry EXPRESSION medicine.medical_specialty Environmental Sciences & Ecology Article MECHANISMS 03 medical and health sciences FEV1/FVC ratio Endurance training Internal medicine Myokine medicine Humans Interleukin 8 Science & Technology business.industry Interleukin-8 lcsh:R Public Health Environmental and Occupational Health 030229 sport sciences Plasma levels cytokines FVC aerobic capacity CYTOKINE 030228 respiratory system ASTHMA business human activities Environmental Sciences |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 8 International Journal of Environmental Research and Public Health, Vol 17, Iss 2622, p 2622 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17082622 |
| Popis: | At present, it is unclear which exercise-induced factors, such as myokines, could diminish the negative impact of the reduction in pulmonary function imposed by the exercise in question. In this study, we aim to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) and also to investigate the effect of myokines in the performance of marathon runners presenting EIB or not. Thirty-eight male recreational marathon runners (age 38.8 [33&ndash 44], height 175.7 [172.0&ndash 180.3] weight 74.7 [69.3&ndash 81.6]) participated in this study, and through spirometry tests, a prevalence of 23.6% of EIB was found, which is in agreement with the literature. The volunteers who tested positive to EIB (EIB+) presented lower maximum aerobic capacity compared to those who tested negative (EIB&minus ) (EIB+ 44.02 [39.56&ndash 47.02] and EIB&minus 47.62 [44.11&ndash 51.18] p = 0.03). The comparison of plasma levels of IL-1&beta (EIB+ p = 0.296, EIB&minus p = 0.176, EIB+ vs. EIB&minus baseline p = 0.190 immediately after p = 0.106), IL-4 (undetectable), IL-6 (EIB+ p = 0.003, EIB&minus p &le 0.001, EIB+ vs. EIB&minus baseline p = 0.301 immediately after p = 0.614), IL-8 (EIB+ p = 0.003, EIB&minus baseline p = 0.110 immediately after p = 0.453), IL-10 (EIB+ p = 0.003, EIB&minus baseline p = 0.424 immediately after p = 0.876) and TNF-&alpha (EIB+ p = 0.003, EIB&minus baseline p = 0.141 immediately after p = 0.898) were similar in both groups 24 h before and immediately after the marathon. However, negative correlations were found between the marathon finishing time and the levels of IL-8 (r = &minus 0.81, p = 0.022), and IL-10 (r = &minus 0.97, p &le 0.001) immediately after completing the marathon. In conclusion, for the first time, it is shown that the myokines IL-8 and IL-10 are related to improvement of the performance of marathon runners presenting EIB. |
| Databáze: | OpenAIRE |
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