Survey on request form content and result reporting in therapeutic drug monitoring service among laboratories in Czechia and Slovakia
| Autor: | Barbora Studená, Tomáš Šálek, Michaela Votroubková, Petr Schneiderka |
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| Rok vydání: | 2019 |
| Předmět: |
Quality Control
030213 general clinical medicine medicine.medical_specialty Slovakia Quality Assurance Health Care Clinical Biochemistry kidney function tests Computer-assisted web interviewing 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires External quality assessment preanalytical phase Medicine Humans clinical laboratory services Medical physics Dosing Czech Republic Service (business) Response rate (survey) drug monitoring Internet medicine.diagnostic_test business.industry Health Policy Biochemistry (medical) Reproducibility of Results Original Articles Positive response Therapeutic drug monitoring business pharmacokinetics Laboratories Renal drug |
| Zdroj: | Biochemia Medica Volume 30 Issue 2 |
| ISSN: | 1846-7482 1330-0962 |
| Popis: | Introduction: The aim of the study was to investigate current practice and policies of therapeutic drug monitoring (TDM) service requesting and result reporting in Czechia and Slovakia. Materials and methods: All 149 laboratories that measure plasma drug concentrations were given an online questionnaire during a regular external quality assessment TDM cycle. The questionnaire consisted of 17 questions. The optimal TDM practice was defined as the application of all elements (age, body weight, time of sampling, date of the first administration, time of the last dose administration, the dose, the dosing interval, the route of administration, information on reason of testing, and information on other co–administered drugs) needed for reporting a recommendation for further drug dosing (positive response to question number 16). Results: The response rate was 69%, 103 out of 149 laboratories measuring drug concentrations. Only 12% (12 out of 103 laboratories) of the laboratories implemented all elements needed for optimal TDM practice and reported a recommendation. Both paper and electronic request forms were used by 77 out of 103 (75%) laboratories. A total of 69 out of 103 laboratories (67%) specified the type of sampling tube on their request form. Cystatin C was used for prediction of renal drug elimination by 24% (25 out of 103) of participants. Conclusions: Small number of laboratories implemented all elements needed for optimal TDM practice and report a recommendation on further dosing. Further efforts in education on optimal TDM practice as well as harmonization of service are desirable. |
| Databáze: | OpenAIRE |
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