Sinonasal Quality of Life Outcomes after Endoscopic Endonasal Transsphenoidal Surgery with Posterior Septum Free Mucosal Graft Reconstruction
| Autor: | Angela Chen, Anthony P. Heaney, Christine Wells, Marilene B. Wang, Marvin Bergsneider, Tara J. Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment sellar reconstruction Clinical Sciences sinonasal morbidity Tertiary care 03 medical and health sciences 0302 clinical medicine Quality of life Clinical Research medicine In patient sinonasal outcome test-22 030223 otorhinolaryngology Cancer Transsphenoidal surgery Neurology & Neurosurgery business.industry free mucosal graft Neurosciences endoscopic endonasal transphenoidal surgery Evaluation of treatments and therapeutic interventions Multilevel regression Brain Disorders Surgery Postoperative visit quality of life Mucosal graft Cohort Neurology (clinical) business 6.4 Surgery 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurological surgery. Part B, Skull base, vol 82, iss 5 J Neurol Surg B Skull Base |
| ISSN: | 2193-634X 2193-6331 |
| DOI: | 10.1055/s-0040-1716678 |
| Popis: | Objective Quality of life (QoL) outcomes following endoscopic endonasal transphenoidal surgery (EETS) across a variety of reconstructive methods improve by 2 to 6 months. An option for sellar reconstruction, in the absence of a significant intraoperative cerebrospinal fluid (CSF) leak, is a free mucosal graft (FMG) from the posterior septum. We analyze sinonasal QoL outcomes in patients undergoing EETS with FMG reconstruction. Study Design This study was a retrospective review. Setting This study was conducted at tertiary care academic center. Participants This study group consisted of patients undergoing EETS for pituitary adenomas from 2013 to 2018. Main Outcome Measures Tumor and surgical factors were included, along with postoperative complications. Patients completed Sinonasal Outcome Test-22 (SNOT-22) questionnaires. Pre- and postoperative scores were compared among the entire cohort using linear multilevel regression. A subcohort analysis was performed among patients who completed questionnaires during the preoperative visit and two postoperative visits (within 1 month and between 2 and 3 months, respectively); pre- and postoperative total and individual domain SNOT-22 scores were compared using paired t-tests. Results A total of 243 patients underwent EETS with FMG reconstruction. Four patients (1.6%) developed a postoperative CSF leak requiring reoperation. Among the entire cohort, SNOT-22 scores increased at the first postoperative visit (p Conclusion Posterior septum FMG reconstruction of sellar defects is an effective option, demonstrating early recovery of baseline sinonasal QoL by 2 to 3 months. |
| Databáze: | OpenAIRE |
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