Migration promotes mutator alleles in subdivided populations
| Autor: | Yevgeniy Raynes, Daniel M. Weinreich, Paul D. Sniegowski |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Mutation rate mutation rate Population structure Population Metapopulation Saccharomyces cerevisiae Biology Brief Communication migration 010603 evolutionary biology 01 natural sciences 03 medical and health sciences Genetics Indirect selection Allele Selection Genetic education sign inversion Ecology Evolution Behavior and Systematics Population Density Microbial pathogenesis education.field_of_study Models Genetic Population size mutator Fixation (population genetics) 030104 developmental biology Evolutionary biology Genome Fungal General Agricultural and Biological Sciences Brief Communications |
| Zdroj: | Evolution; International Journal of Organic Evolution |
| ISSN: | 1558-5646 |
| Popis: | Mutator alleles that elevate the genomic mutation rate may invade nonrecombining populations by hitchhiking with beneficial mutations. Mutators have been repeatedly observed to take over adapting laboratory populations and have been found at high frequencies in both microbial pathogen and cancer populations in nature. Recently, we have shown that mutators are only favored by selection in sufficiently large populations and transition to being disfavored as population size decreases. This population size‐dependent sign inversion in selective effect suggests that population structure may also be an important determinant of mutation rate evolution. Although large populations may favor mutators, subdividing such populations into sufficiently small subpopulations (demes) might effectively inhibit them. On the other hand, migration between small demes that otherwise inhibit hitchhiking may promote mutator fixation in the whole metapopulation. Here, we use stochastic, agent‐based simulations and evolution experiments with the yeast Saccharomyces cerevisiae to show that mutators can, indeed, be favored by selection in subdivided metapopulations composed of small demes connected by sufficient migration. In fact, we show that population structure plays a previously unsuspected role in promoting mutator success in subdivided metapopulations when migration is rare. |
| Databáze: | OpenAIRE |
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