Monitoring mitochondrial PO2: the next step
| Autor: | Floor A. Harms, Egbert G. Mik, Gianmarco M Balestra |
|---|---|
| Přispěvatelé: | Anesthesiology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Critically ill Microcirculation Apparent oxygen utilisation 030208 emergency & critical care medicine Cellular level Critical Care and Intensive Care Medicine University hospital Oxygen tension Mitochondria Oxygen 03 medical and health sciences 0302 clinical medicine Oxygen Consumption 030228 respiratory system Intensive care Healthy volunteers Oxygen delivery Medicine Animals Humans Blood Gas Analysis business Intensive care medicine |
| Zdroj: | Current Opinion in Critical Care, 26(3), 289-295. Lippincott Williams & Wilkins |
| ISSN: | 1070-5295 |
| Popis: | Purpose of review To fully exploit the concept of hemodynamic coherence in resuscitating critically ill one should preferably take into account information about the state of parenchymal cells. Monitoring of mitochondrial oxygen tension (mitoPO2) has emerged as a clinical means to assess information of oxygen delivery and oxygen utilization at the mitochondrial level. This review will outline the basics of the technique, summarize its development and describe the rationale of measuring oxygen at the mitochondrial level. Recent findings Mitochondrial oxygen tension can be measured by means of the protoporphyrin IX-Triplet State Lifetime Technique (PpIX-TSLT). After validation and use in preclinical animal models, the technique has recently become commercially available in the form of a clinical measuring system. This system has now been used in a number of healthy volunteer studies and is currently being evaluated in studies in perioperative and intensive care patients in several European university hospitals. Summary PpIX-TSLT is a noninvasive and well tolerated method to assess aspects of mitochondrial function at the bedside. It allows doctors to look beyond the macrocirculation and microcirculation and to take the oxygen balance at the cellular level into account in treatment strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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