Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study
| Autor: | Bao-Ping Yu, Ai-Ying Yang, Tao Xiong, Xin-Ying Zhao, Zhi-Ping Huang, Yuan-Yan Tang, Hai-Sen Yin, Qin-Ming Hu, Xuan-Xuan Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Diarrhea Male China medicine.medical_specialty Fever Pneumonia Viral COVID-19 Mortality Respiratory failure Non-respiratory injury Disease characteristics Disease 030204 cardiovascular system & hematology Disease Outbreaks lcsh:Infectious and parasitic diseases Betacoronavirus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medical microbiology Internal medicine Humans Medicine lcsh:RC109-216 030212 general & internal medicine Pandemics Fatigue Retrospective Studies Creatinine SARS-CoV-2 business.industry Mortality rate Outbreak Retrospective cohort study Middle Aged Infectious Diseases Cough chemistry Female medicine.symptom Coronavirus Infections Tomography X-Ray Computed business Research Article |
| Zdroj: | BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-8 (2020) BMC infectious diseases, 20(1):311 BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-020-05010-w |
| Popis: | Background Since December 2019, the 2019 coronavirus disease (COVID-19) has expanded to cause a worldwide outbreak that more than 600,000 people infected and tens of thousands died. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. Methods We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. Results Of the 91 patients diagnosed with COVID-19, 30 cases (33.0%) were severe and two patients (2.2%) died. The severe disease group tended to be older (50.5 vs. 42.0 years; p = 0.049) and have more chronic disease (40% vs. 14.8%; p = 0.009) relative to mild disease group. Only 73.6% of the patients were quantitative polymerase chain reaction (qPCR)-positive on their first tests, while typical chest computed tomography images were obtained for each patient. The most common complaints were cough (n = 75; 82.4%), fever (n = 59; 64.8%), fatigue (n = 35; 38.5%), and diarrhea (n = 14; 15.4%). Non-respiratory injury was identified by elevated levels of aspartate aminotransferase (n = 18; 19.8%), creatinine (n = 5; 5.5%), and creatine kinase (n = 14; 15.4%) in laboratory tests. Twenty-eight cases (30.8%) suffered non-respiratory injury, including 50% of the critically ill patients and 21.3% of the mild patients. Conclusions Overall, the mortality rate of patients in Jingzhou was lower than that of Wuhan. Importantly, we found liver, kidney, digestive tract, and heart injuries in COVID-19 cases besides respiratory problems. Combining chest computed tomography images with the qPCR analysis of throat swab samples can improve the accuracy of COVID-19 diagnosis. |
| Databáze: | OpenAIRE |
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