Adrenocorticotropic Hormone Secreting Pituitary Carcinoma: Rare, Durable Response to Concurrent Chemotherapy and Reirradiation With a Review of the Literature
| Autor: | Katherine Albano, Nathan T. Zwagerman, Joseph Bovi, Megan Orr, Jennifer Connelly, James W. Findling |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty Temozolomide business.industry medicine.medical_treatment Pituitary tumors Teaching Case R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Adrenocorticotropic hormone Malignancy medicine.disease Radiation therapy Medical physics. Medical radiology. Nuclear medicine Internal medicine Pituitary carcinoma Hypoadrenalism medicine Endocrine system Radiology Nuclear Medicine and imaging business RC254-282 medicine.drug |
| Zdroj: | Advances in Radiation Oncology, Vol 7, Iss 2, Pp 100813-(2022) Advances in Radiation Oncology |
| ISSN: | 2452-1094 |
| Popis: | Pituitary carcinoma (PC) is an uncommon intracranial malignancy with a high rate of metastasis, mortality, and inconsistent response to therapy. Because PC is a rare condition (0.1%-0.2% of pituitary tumors), prospective studies and observable data are scarce. Some PC may have an endocrine secretory function and can arise from existing pituitary adenomas. Treatment often includes a combination of surgical resection, radiotherapy, and systemic therapies. Because of the poor treatment response rate and rapid progression, treatment is often palliative. Here we describe a unique, complete amelioration of severe Cushing's disease due to an ACTH secreting pituitary carcinoma followed by the development of pituitary hypoadrenalism after re-irradiation with concurrent temozolomide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|