Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts
| Autor: | Robert Gurny, Frédéric Lallemand, Simon Benita, Jean-Sebastien Garrigue, Jean-Louis Bourges, Mathieu Schmitt |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Large molecular weight genetic structures Drug Industry Eye Diseases Drug Compounding Pharmaceutical Science 02 engineering and technology Disease 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems medicine Animals Humans Intensive care medicine Drug industry Drug compounding Academic Medical Centers business.industry General Medicine 021001 nanoscience & nanotechnology medicine.disease eye diseases Ophthalmic solutions Drug delivery 030221 ophthalmology & optometry Cyclosporine sense organs Ophthalmic Solutions 0210 nano-technology business Vernal keratoconjunctivitis Uveitis Immunosuppressive Agents Biotechnology |
| Zdroj: | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 117 |
| ISSN: | 1873-3441 |
| Popis: | Local ocular delivery of cyclosporine A (CsA) is the preferred method for CsA delivery as a treatment for ocular inflammatory diseases such as uveitis, corneal healing, vernal keratoconjunctivitis and dry eye disease. However, due to the large molecular weight and hydrophobic nature of CsA and the natural protective mechanisms of the eye, achieving therapeutic levels of CsA in ocular tissues can be difficult. This review gives a comprehensive overview of the current products available to clinicians as well as emerging drug delivery solutions that have been developed at both the academic and industry levels. |
| Databáze: | OpenAIRE |
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