Prevalence, risk factors and main features of adverse drug reactions leading to hospital admission
| Autor: | Consuelo Pedrós, Josep Maria Arnau, Mireia Rebolledo, Antoni Vallano, Beatriz Quintana, Nuria Porta |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Drug-Related Side Effects and Adverse Reactions Cross-sectional study Young Adult Risk Factors Pharmacovigilance Prevalence medicine Clinical endpoint Humans Pharmacology (medical) Drug reaction Young adult Adverse effect Aged Aged 80 and over Pharmacology Polypharmacy business.industry Age Factors General Medicine Length of Stay Middle Aged medicine.disease Hospitalization Cross-Sectional Studies Emergency medicine Female Upper gastrointestinal bleeding business |
| Zdroj: | European Journal of Clinical Pharmacology. 70:361-367 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-013-1630-5 |
| Popis: | To assess the prevalence of hospital admission related to adverse drug reactions (ADRs) in a third-level hospital, to analyse the associated factors, and to describe the reactions and the drugs involved. A cross-sectional study was conducted for a 120-day period. Patients that were urgently hospitalized entered the study. The primary endpoint was the ADR-related urgent admission. A descriptive analysis of demographic, clinical, and drug-related variables was performed. The association between the likelihood of urgent admission due to ADRs and age, gender, and number of drugs used was analysed. A descriptive analysis of the suspected drugs and the reactions in ADR-related admissions was performed. Overall, 186 out of 4,403 hospital admissions were due to ADRs (prevalence: 4.2 % [95 % CI 3.7–4.8 %]). Age (≥65 years: OR 1.59 [95 % CI 1.10–2.29]) and number of drugs used at the time of admission (3–5 drugs: OR 5.07 [95 % CI 2.71–9.59]; 6–9 drugs: OR 5.90 [95 % CI 3.16–11.0]; ≥10 drugs: OR 8.94 [95 % CI 4.73–16.89]), but not gender, were identified as independent factors associated with ADR-related hospitalization. The overall in-hospital stay for patients admitted with ADRs amounted to 1,785 days. The ADRs were mainly type A reactions (92 %). Acute renal failure related to renin-angiotensin system inhibitors, haemorrhage due to anticoagulants, and upper gastrointestinal bleeding related to antiplatelet drugs and/or non-steroidal anti-inflammatory drugs were the most frequent. Over 4 % of urgent hospitalizations are caused by ADRs, which are dose-related and predictable in more than 90 % of cases. The main risk factors are advanced age and polypharmacy. |
| Databáze: | OpenAIRE |
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