Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors
| Autor: | Jose Costa, Richard A. Knazek, Carole Yee |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Stromal cell Metabolite Chondrosarcoma Radioimmunoassay Mice Nude Prostaglandin Soft Tissue Neoplasms Arachidonic Acids Biology Embryonal carcinoma Mice Sarcoma Synovial chemistry.chemical_compound Hydroxyeicosatetraenoic Acids Rhabdomyosarcoma medicine Animals Humans Chromatography High Pressure Liquid Arachidonic Acid Histiocytoma Benign Fibrous Teratoma Hydroxyeicosatetraenoic acid Sarcoma medicine.disease Oncology chemistry Prostaglandins Cancer research Alveolar rhabdomyosarcoma Arachidonic acid Chromatography Thin Layer Neoplasm Transplantation |
| Zdroj: | International Journal of Cancer. 36:143-152 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910360204 |
| Popis: | The metabolism of arachidonic acid was investigated by radioimmunoassay and chromatographic techniques in 5 sarcomas and one embryonal carcinoma of human origin maintained as transplantable tumors in nude mice. The results obtained indicate that: (1) the absolute quantities of arachidonic acid metabolites produced by a given tumor varied between experiments but the overall distribution pattern of these products, in general, remained constant from passage to passage; (2) each tumor showed a different arachidonic acid metabolite profile in quality and quantity; (3) 2 sarcomas of the same histological type could be clearly distinguished by their arachidonic acid metabolites; (4) the predominant product in all tumors was 12-HETE3 or 15-HETE, whereas thromboxane A2 was synthesized in low quantities by all tumors; (5) PGF2α was synthesized at the highest rate by an alveolar rhabdomyosarcoma; (6) PGE2 synthesis was highest in a malignant fibrous histiocytoma; and (7) total prostaglandin synthesis was low in the chondrosarcoma and synovial-cell sarcomas. All results reported in this study are for the complete tumor which includes both neoplastic and stromal cells. The role that these products play in the biological behavior of mesenchymal tumor cells and normal tissues of the host remains to be determined. |
| Databáze: | OpenAIRE |
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