The usefulness of commercially available serological tests in the diagnosis and monitoring of treatment in patients with alveolar echinococcosis
| Autor: | Wojciech Wołyniec, Beata Szostakowska, Wacław Nahorski, Małgorzata Sulima, Piotr Wąż, Katarzyna Sikorska |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Original Paper Hepatology biology medicine.diagnostic_test business.industry medicine.medical_treatment serology Alveolar echinococcosis Liver transplantation biology.organism_classification Echinococcus multilocularis medicine.disease Echinococcosis Gastroenterology Serology Echinococcus Western blot echinococcosis Internal medicine parasitic diseases alveolar echinococcosis Medicine Radical surgery business |
| Zdroj: | Clinical and Experimental Hepatology |
| ISSN: | 2449-8238 2392-1099 |
| Popis: | Aim of the study To assess the clinical usefulness of serological tests in the diagnosis and monitoring of treatment of patients with alveolar echinococcosis (AE). Material and methods The results of serological tests, i.e. Echinococcus multilocularis ELISA (Bordier Affinity Products) and Echinococcus Western Blot IgG (LDBIO Diagnostic), of 66 patients were analysed. Duration of follow-up was two years after diagnosis. In the second phase of the study 11 sera obtained from the patients undergoing surgical treatment, in whom the results of Echinococcus Western Blot IgG assay were still positive, were additionally tested with Anti-Echinococcus EUROLINE-WB (IgG) assay. Results Statistically significant negativization of the Echinococcus multilocularis ELISA test was observed in the group of patients who underwent radical surgery or liver transplantation. Negativization of Echinococcus Western Blot IgG assay results was observed in some patients, among both those who received conservative treatment and those who underwent surgery, but no statistically significant differences were found between treatment groups. In 54.5% of cases the Anti-Echinococcus EUROLINE-WB (IgG) test result was negative when the results of the Echinococcus Western Blot IgG assay were still positive. Conclusions Echinococcus multilocularis ELISA proved to be useful in assessing the activity of AE in a group of patients who underwent radical surgery or liver transplantation. The results of our study suggest that Anti-Echinococcus EUROLINE-WB (IgG) is a more dynamic test, which at the time of disappearance of AE activity becomes negative earlier. |
| Databáze: | OpenAIRE |
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