Flexible dosing with Darbepoetin alfa for the treatment of chemotherapy-induced anemia
| Autor: | K Pat, Johan Vansteenkiste, Isabelle Wauters |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Oncology
medicine.medical_specialty Darbepoetin alfa Anemia medicine.medical_treatment Review erythropoietic therapy Quality of life Internal medicine medicine Pharmacology (medical) Dosing chemotherapy-induced anemia General Pharmacology Toxicology and Pharmaceutics Intensive care medicine Chemotherapy clinical trials Chemical Health and Safety business.industry Cancer General Medicine medicine.disease anemia quality of life Erythropoietin Hemoglobin business Safety Research pharmacokinetics medicine.drug |
| Zdroj: | Therapeutics and Clinical Risk Management |
| ISSN: | 1178-203X 1176-6336 |
| Popis: | Anemia is frequent in cancer patients with chemotherapy, and has an important negative effect on health-related quality of life (QoL). Darbepoetin alfa belongs to a new class of erythropoietic proteins with a unique molecular structure and interesting properties compared with classic recombinant human erythropoietin. Darbepoetin alfa is effective for chemotherapy-induced anemia when administered once weekly at a dose of 2.25 mug/kg, as shown in two large phase III placebo-controlled trials in patients with solid tumors and hematological malignancies. Furthermore, it was safe and well tolerated. More recently attention has been focused on optimizing Darbepoetin alfa therapy. Front-loaded dosing was explored to accelerate the hemoglobin (Hb) response and effect on QoL, but this idea could not be confirmed in a large phase III study. Based on the prolonged half-life of Darbepoetin alfa, administration every 3 weeks was appealing. In a large phase III trial, noninferiority of administration of 500 mug every 3 weeks compared with the weekly dosing could be confirmed, both in terms of reduction of red blood cell transfusion, Hb parameters, and QoL. This schedule is very convenient for patients and caregivers as it allows synchronization of erythropoietic therapy and common chemotherapy schedules. Questions for future study are the optimal iron supplementation strategy and the effect of Darbepoetin alfa on outcome. This article reviews the clinical development of Darbepoetin alfa with emphasis on recent data. |
| Databáze: | OpenAIRE |
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