Severe Occupational Asthma: Insights From a Multicenter European Cohort
| Autor: | Olivier Vandenplas, Julien Godet, Laura Hurdubaea, Catherine Rifflart, Hille Suojalehto, Jolanta Walusiak-Skorupa, Xavier Munoz, Joaquin Sastre, Pavlina Klusackova, Vicky Moore, Rolf Merget, Donatella Talini, Jorunn Kirkeleit, Paola Mason, Ilenia Folletti, Paul Cullinan, Gianna Moscato, Santiago Quirce, Jennifer Hoyle, David Sherson, Paula Kauppi, Alexandra Preisser, Nicolas Meyer, Frédéric de Blay, Pirjo Hölttä, Alexandra M. Preisser, Volker Harth, Piero Maestrelli, Patrizia Pignatti, Pierluigi Paggiaro, Marco dell’Omo, Ilenia Foletti, Cecilie Svanes, Marta Wiszniewska, Christian Romero-Mesones, Mar Fernandez-Nieto, Marta Sanchez-Jareno, Julie Cannon, Sherwood Burge |
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| Přispěvatelé: | UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Clinicum, Helsinki University Hospital Area |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Allergy Severe asthma ADULT-ONSET ASTHMA Logistic regression Severity of Illness Index INHALATION CHALLENGE Specific inhalation challenge 0302 clinical medicine Risk Factors Forced Expiratory Volume Odds Ratio Immunology and Allergy Medicine 030212 general & internal medicine Asthma Occupational PREDICTORS Occupational asthma Middle Aged PREVALENCE 3. Good health Europe Cohort Female Life Sciences & Biomedicine PROVOCATION TESTS Adult medicine.medical_specialty Immunology European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) investigators DIAGNOSIS 03 medical and health sciences Internal medicine Occupational Exposure Asthma control MANAGEMENT Humans Airflow obstruction EXPOSURE Asthma exacerbations Adrenergic beta-2 Receptor Agonists Asthma Retrospective Studies Science & Technology business.industry Retrospective cohort study NONSPECIFIC BRONCHIAL HYPERRESPONSIVENESS Odds ratio medicine.disease EXACERBATIONS 030228 respiratory system 3121 General medicine internal medicine and other clinical medicine business |
| Zdroj: | The journal of allergy and clinical immunology. In practice, Vol. 7, no. 7, p. 2309-2318 (2019) Vandenplas, O, Godet, J, Hurdubaea, L, Rifflart, C, Suojalehto, H, Walusiak-Skorupa, J, Munoz, X, Sastre, J, Klusackova, P, Moore, V, Merget, R, Talini, D, Kirkeleit, J, Mason, P, Folletti, I, Cullinan, P, Moscato, G, Quirce, S, Hoyle, J, Sherson, D, Kauppi, P, Preisser, A, Meyer, N, de Blay, F, Hölttä, P, Preisser, A M, Harth, V, Maestrelli, P, Pignatti, P, Paggiaro, P, dell'Omo, M, Foletti, I, Svanes, C, Wiszniewska, M, Romero-Mesones, C, Fernandez-Nieto, M, Sanchez-Jareno, M, Cannon, J, Burge, S & European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) investigators 2019, ' Severe Occupational Asthma : Insights From a Multicenter European Cohort ', Journal of Allergy and Clinical Immunology: In Practice, vol. 7, no. 7, pp. 2309-2318.e4 . https://doi.org/10.1016/j.jaip.2019.03.017 2318.e4 |
| Popis: | BACKGROUND: Although sensitizer-induced occupational asthma (OA) accounts for an appreciable fraction of adult asthma, the severity of OA has received little attention. OBJECTIVE: The aim of this study was to characterize the burden and determinants of severe OA in a large multicenter cohort of subjects with OA. METHODS: This retrospective study included 997 subjects with OA ascertained by a positive specific inhalation challenge completed in 20 tertiary centers in 11 European countries during the period 2006 to 2015. Severe asthma was defined by a high level of treatment and any 1 of the following criteria: (1) daily need for a reliever medication, (2) 2 or more severe exacerbations in the previous year, or (3) airflow obstruction. RESULTS: Overall, 162 (16.2%; 95% CI, 14.0%-18.7%) subjects were classified as having severe OA. Multivariable logistic regression analysis revealed that severe OA was associated with persistent (vs reduced) exposure to the causal agent at work (odds ratio [OR], 2.78; 95% CI, 1.50-5.60); a longer duration of the disease (OR, 1.04; 95% CI, 1.00-1.07); a low level of education (OR, 2.69; 95% CI, 1.73-4.18); childhood asthma (OR, 2.92; 95% CI, 1.13-7.36); and sputum production (OR, 2.86; 95% CI, 1.87-4.38). In subjects removed from exposure, severe OA was associated only with sputum production (OR, 3.68; 95% CI, 1.87-7.40); a low education level (OR, 3.41; 95% CI, 1.72-6.80); and obesity (OR, 1.98; 95% CI, 0.97-3.97). CONCLUSIONS: This study indicates that a substantial proportion of subjects with OA experience severe asthma and identifies potentially modifiable risk factors for severe OA that should be targeted to reduce the adverse impacts of the disease. (C) 2019 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology |
| Databáze: | OpenAIRE |
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