Biological therapy downregulates the heterodimer S100A8/A9 (calprotectin) expression in psoriatic patients
| Autor: | Evangelia Skarmoutsou, P. Gangemi, V. Longo, Fabio D’Amico, M. Pettinato, G. Lovero, Maria Clorinda Mazzarino, Mariagrazia Granata, Chiara Trovato |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Immunology Anti-Inflammatory Agents Down-Regulation Inflammation Biological therapy Calprotectin Psoriasis S100A8/A9 Biological Therapy Calgranulin A Calgranulin B Female Humans Middle Aged Skin Adalimumab Anti-Inflammatory Agents Non-Steroidal Dermatologic Agents Etanercept Ustekinumab S100A8 03 medical and health sciences medicine Pharmacology business.industry medicine.disease 030104 developmental biology medicine.anatomical_structure Cancer research medicine.symptom business Keratinocyte Non-Steroidal medicine.drug |
| Zdroj: | Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 67(7) |
| ISSN: | 1420-908X |
| Popis: | The pathophysiology of psoriasis is very complex and involves an interplay between immune cells and keratinocytes. The keratinocyte production of calprotectin (S100A8/A9), induced by the inflammatory psoriatic milieu, may be involved in initiating immune cell invasion, as well as in propagating inflammation. However, the exact role of calprotectin in psoriasis remains unclear. Therapeutic approaches utilizing adalimumab, etanercept and ustekinumab are widely used in psoriatic treatment, but their anti-inflammatory mechanisms are not fully understood. The aim of this study was to investigate, by immunohistochemical analysis, the expression of the heterocomplex S100A8/A9 in lesional skin from psoriatic patients undergoing biological therapy with adalimumab, etanercept or ustekinumab. Our results showed that S100A8/A9, absent or present at very low level in skin biopsies from healthy subjects, is dramatically upregulated in each epidermal layer from psoriatic patients. Interestingly, calprotectin was mainly localized in keratinocyte nuclei from psoriatic patients, suggesting a role of S100A8/A9 in keratinocyte nuclear function. Furthermore, we have shown that the biological treatment induced a drastic reduction of S100A8/A9 expression in skin biopsies from treated patients, correlating with PASI reduction. Our results suggest that calprotectin may play a crucial role as a significant marker of inflammation in psoriasis, and that its reduction of expression may be considered a favourable prognostic marker in psoriasis. |
| Databáze: | OpenAIRE |
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