Change in folate status with antidepressant treatment
| Autor: | Russell T. Joffe, Anthony J. Levitt, Virginia Wesson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes medicine.medical_treatment Personality Assessment Gastroenterology Imipramine Serum folate Folic Acid Internal medicine medicine Humans Cyanocobalamin Longitudinal Studies Biological Psychiatry Depression (differential diagnoses) Chemotherapy Depressive Disorder Body Weight Desipramine Middle Aged Psychiatry and Mental health Vitamin B 12 Mood Endocrinology Cross-Sectional Studies Antidepressant Female Age of onset Psychology medicine.drug |
| Zdroj: | Psychiatry research. 53(3) |
| ISSN: | 0165-1781 |
| Popis: | Ninety-nine consecutive unmedicated outpatients with a major depressive illness had blood drawn for measurement of serum folate (SF), red cell folate (RCF), and vitamin B 12 within 24 hours of completion of ratings of severity of depression at the beginning and ending of a 5-week trial of desmethylimipramine (mean dose = 149.2 mg/day, range = 75–225 mg). As compared with nonresponders, responders had a significantly higher mean SF at baseline (nonresponders = 13.8 nmol/1; responders = 17.7 nmol/1) and RCF showed a significant inverse correlation with severity of depression and a significant positive correlation with age of onset of illness. At week 5, change in severity of depression was significantly correlated with change in RCF, and significantly more responders than nonresponders had an increase in RCF. The possible role of folate status in the regulation of mood and response to treatment is discussed. |
| Databáze: | OpenAIRE |
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