Uremia in Sickle-Cell Anemia Treated by Maintenance Hemodialysis
| Autor: | A Smith, C L Sprung, Thomas Manis, Rao Tk, D M Holden, Richard D. Levere, R Bellevue, Eli A. Friedman, Khalid M. H. Butt |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Kidney Cortex Time Factors Anemia medicine.medical_treatment Arteriovenous fistula Cardiomegaly Anemia Sickle Cell Nephropathy Leukocyte Count Arteriovenous Shunt Surgical Renal Dialysis medicine Humans Blood Transfusion Dialysis Uremia medicine.diagnostic_test business.industry Angiography General Medicine medicine.disease Sickle cell anemia Blood Cell Count Surgery Hematocrit Heart failure Kidney Failure Chronic Female Renal biopsy business |
| Zdroj: | New England Journal of Medicine. 291:431-435 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm197408292910902 |
| Popis: | Renal failure, which developed in two patients with sickle-cell anemia, was treated by maintenance hemodialysis for six and seven months. Medullary cystic disease appeared to cause the uremia in a 32-year-old black man with sickle-cell anemia; in the second patient, a 24-year-old black woman, histologic changes in a renal biopsy were consistent with So-Called "sickle nephropathy." When uremia supervened each patient's transfusion requirement, which had been stable at 2 units per month, increased abruptly to 5 and 6 units per month, and then fell, upon initiation of maintenance hemodialysis, to 1 unit per month. Vascular access for dialysis was provided by an internal arteriovenous fistula in one patient and an arterioarterial bovine carotid heterograft in the other. There were neither hemorrhagic nor thrombotic complications of the dialysis regimen. Coincident congestive heart failure in both patients responded well to digitalis. (N Engl J Med 291: 431–435, 1974) |
| Databáze: | OpenAIRE |
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