Biological effects of the immunomodulator beta 1-3D polyglucose are strongly potentiated by conjugation to biodegradable microbeads

Autor:	A. Berge, Q. Gao, Rolf Seljelid, J. Ugelstad
Rok vydání:	1997
Předmět:	beta-Glucans Immunology Biocompatible Materials medicine.disease_cause Beta-1 adrenergic receptor Mice Adjuvants Immunologic medicine Animals Immunologic Factors Beta (finance) Escherichia coli Glucans Biotransformation Escherichia coli Infections Mice Inbred BALB C Chemistry Albumin Long-term potentiation Drug Synergism General Medicine In vitro Microspheres Mice Inbred C57BL Biochemistry Covalent bond Female Conjugate Interleukin-1
Zdroj:	Scandinavian journal of immunology. 45(6)
ISSN:	0300-9475
Popis:	It is demonstrated that the biological effects of the immunomodulator beta 1-3D polyglucose, when covalently linked to polymethacrylate or biodegradable albumin microbeads, are strongly potentiated. The potentiation is recorded as an increased protection effect of the conjugates in Escherichia coli sepsis in mice, and as increased IL-1 production by murine macrophages in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd86c5fe4e80b40a3e94793e97fee4a https://pubmed.ncbi.nlm.nih.gov/9201309 Zobrazit plný text záznamu Plný text