A series of non-quinoline cysLT1 receptor antagonists: Sar study on pyridyl analogs of singulair®

Autor:	C. S. Mcfarlane, Robert Zamboni, C. Rochette, M. McAuliffe, Claude Dufresne, P. Prasit, Jacques-Yves Gauthier, Nicole Sawyer, P. Roy, Kathleen M. Metters, Thomas R. Jones, Daniel Guay
Rok vydání:	1998
Předmět:	Cyclopropanes Leukotriene D4 Pyridines Stereochemistry Guinea Pigs Clinical Biochemistry Pharmaceutical Science Acetates Sulfides Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Animals Humans Structure–activity relationship Anti-Asthmatic Agents Receptor Saimiri Molecular Biology Montelukast Receptors Leukotriene Leukotriene Bicyclic molecule Chemistry Organic Chemistry Quinoline Membrane Proteins Rats Quinolines Leukotriene Antagonists Molecular Medicine medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:453-458
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(98)00051-1
Popis:	The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd676ec687126fd854a185ba05701c3 https://doi.org/10.1016/s0960-894x(98)00051-1 Zobrazit plný text záznamu Full Text from ScienceDirect