Deciphering the Non-Coding RNA Landscape of Pediatric Acute Myeloid Leukemia
| Autor: | Jolien Vanhooren, Laurens Van Camp, Barbara Depreter, Martijn de Jong, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Marie-Françoise Dresse, Jutte van der Werff ten Bosch, Mattias Hofmans, Jan Philippé, Barbara De Moerloose, Tim Lammens |
|---|---|
| Přispěvatelé: | Hematology, Clinical sciences, Clinical Biology, Growth and Development, Pediatrics, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
EXPRESSION
Cancer Research Science & Technology hematology non-coding RNA PROLIFERATION PROGRESSION CANCER GENE APOPTOSIS Oncology pediatric AML cellular subpopulations hemic and lymphatic diseases oncology Medicine and Health Sciences Internal Medicine SUPPRESSES Pediatrics Perinatology and Child Health Non-coding RNA Life Sciences & Biomedicine STEM-CELLS |
| Zdroj: | CANCERS Cancers, Vol. 14, p. 3-15 (2022) Cancers; Volume 14; Issue 9; Pages: 2098 |
| ISSN: | 2072-6694 |
| Popis: | Pediatric acute myeloid leukemia (pedAML) is a heterogeneous blood cancer that affects children. Although survival rates have significantly improved over the past few decades, 20-30% of children will succumb due to treatment-related toxicity or relapse. The molecular characterization of the leukemic stem cell, shown to be responsible for relapse, is needed to improve treatment options and survival. Recently, it has become clear that non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play a role in the development of human diseases, including pediatric cancer. Nevertheless, non-coding RNA expression data in pedAML are scarce. Here, we explored lncRNA (n = 30,168) and miRNA (n = 627) expression in pedAML subpopulations (leukemic stem cells (LSCs) and leukemic blasts (L-blasts)) and their normal counterparts (hematopoietic stem cells and control myeloblasts). The potential regulatory activity of differentially expressed lncRNAs in LSCs (unique or shared with the L-blast comparison) on miRNAs was assessed. Moreover, pre-ranked gene set enrichment analyses of (anti-) correlated protein-coding genes were performed to predict the functional relevance of the differentially upregulated lncRNAs in LSCs (unique or shared with the L-blast comparison). In conclusion, this study provides a catalog of non-coding RNAs with a potential role in the pathogenesis of pedAML, paving the way for further translational research studies. ispartof: CANCERS vol:14 issue:9 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|