Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals
| Autor: | Sabri Ahmed Rial, Catherine Mounier, Karl-F. Bergeron, Antony D. Karelis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
obesity medicine.medical_specialty Firmicutes lcsh:TX341-641 030209 endocrinology & metabolism Review Type 2 diabetes Gut flora Systemic inflammation metabolic syndrome 03 medical and health sciences 0302 clinical medicine Insulin resistance medium chain triglycerides Weight loss metabolically healthy obese Internal medicine medicine Humans Triglycerides Nutrition and Dietetics gut microbiota biology Bacteroidetes endotoxemia medium chain fatty acids metabolically unhealthy obese lipopolysaccharide Fatty liver non-alcoholic fatty liver disease medicine.disease biology.organism_classification Obesity Diet 030104 developmental biology Endocrinology medicine.symptom Metabolic syndrome lcsh:Nutrition. Foods and food supply Food Analysis Food Science |
| Zdroj: | Nutrients, Vol 8, Iss 5, p 281 (2016) Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu8050281 |
| Popis: | Obesity and associated metabolic complications, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D), are in constant increase around the world. While most obese patients show several metabolic and biometric abnormalities and comorbidities, a subgroup of patients representing 3% to 57% of obese adults, depending on the diagnosis criteria, remains metabolically healthy. Among many other factors, the gut microbiota is now identified as a determining factor in the pathogenesis of metabolically unhealthy obese (MUHO) individuals and in obesity-related diseases such as endotoxemia, intestinal and systemic inflammation, as well as insulin resistance. Interestingly, recent studies suggest that an optimal healthy-like gut microbiota structure may contribute to the metabolically healthy obese (MHO) phenotype. Here, we describe how dietary medium chain triglycerides (MCT), previously found to promote lipid catabolism, energy expenditure and weight loss, can ameliorate metabolic health via their capacity to improve both intestinal ecosystem and permeability. MCT-enriched diets could therefore be used to manage metabolic diseases through modification of gut microbiota. |
| Databáze: | OpenAIRE |
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