Colorectal cancer and trace elements alteration
| Autor: | Jovan T. Juloski, Saša Janković, Dragica Nikolic, Alexander M. Trbovich, Vladica V. Ćuk, Vladimir Čuk, Srđan Stefanović, Aleksandar D. Rakić, Silvio R. De Luka |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Quality Assurance Health Care Colorectal cancer Colon Population Cell Healthy tissue 010501 environmental sciences 01 natural sciences Biochemistry Gastroenterology Mass Spectrometry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Colon carcinoma Internal medicine medicine Humans Colorectal adenocarcinoma education 0105 earth and related environmental sciences Aged education.field_of_study business.industry Dietary intake Cancer Middle Aged medicine.disease 3. Good health Trace Elements medicine.anatomical_structure 13. Climate action Molecular Medicine Female business Colorectal Neoplasms 030217 neurology & neurosurgery |
| Zdroj: | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 59 |
| ISSN: | 1878-3252 |
| Popis: | Background Trace elements have important influence on body function primarily because of the vital role they have in many physiological processes. Their alterations have been found in many disorders, including cancer. It has been well known for decades that disturbances in elemental concentration may lead to cell damaging, DNA injuries and imbalance in oxidative burden. Our study tried to determine the difference of trace elements concentrations between colorectal adenocarcinoma and adjacent healthy intestinal tissue. Methods 59 subjects participated in this study. Healthy colon mucosa samples and colon tumor tissue samples were obtained from patients previously diagnosed with colon carcinoma by standard diagnostic procedures. Analysis of the elements was performed by inductively coupled plasma mass spectrometry (ICP-MS). Results The results showed that Na, K, Mg, Ca, Cu, Zn, Se, Mn, Cd, Cr and Hg significantly differ between malignant tissue of colorectal cancer (CRC) and adjacent healthy bowel tissue. We have, also, found that Cu/Zn tissue ratio was significantly higher in CRC compared to a healthy tissue and that patients with higher CRC stages had also significantly higher ratio. Conclusions Since this is the first such study in Balkan region, we assume that results of our study could be a good indicator of elemental alterations in colorectal cancer of Balkan population, due to similarity in lifestyle, dietary intake, pollution and exposure to toxic elements. |
| Databáze: | OpenAIRE |
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