Tumor size is a major determinant of recurrence in patients with resectable gastrointestinal stromal tumor
| Autor: | Ta Ming Yang, Pin Wen Lin, Kai Hsi Hsu, Yan Shen Shan |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Prognostic factor Poor prognosis medicine.medical_specialty Stromal cell Gastrointestinal Stromal Tumors Gastroenterology Risk Factors Internal medicine Adjuvant therapy Humans Medicine In patient Stromal tumor Digestive System Surgical Procedures Aged Retrospective Studies Aged 80 and over Gastrointestinal tract Tumor size business.industry General Medicine Middle Aged digestive system diseases Tumor Burden Survival Rate Female Surgery Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | The American Journal of Surgery. 194:148-152 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2006.10.033 |
| Popis: | Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the mainstay of curative treatment. Recurrence after surgery was frequent and was associated with poor prognosis. In this study, we tried to identify predictors of recurrence in resectable GISTs. Methods Between January 1995 and December 2005, 100 patients undergoing surgical resection for GISTs in 2 hospitals were studied. Results There were 67 gastric and 33 intestinal GISTs. Recurrence was noted in 11 patients (median follow-up of 43 months). Overall 5-year survival was 84%. Multivariate analysis demonstrated that tumor size ≥10 cm was associated with higher recurrence rates ( P = .032) and was the only independent poor prognostic factor for survival ( P = .020). Conclusions We concluded that tumor size ≥10 cm carried both a higher risk of recurrence and worse survival in resectable GISTs and could be considered an indicator for adjuvant therapy. |
| Databáze: | OpenAIRE |
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