Effect of vitamin D supplementation on markers of vascular function: a systematic review and individual participant meta‐analysis

Autor: Adam D. Gepner, Maria Gisella Cavallo, Alexandra Scholze, Jane Armitage, Frank H Mose, Marina Shargorodsky, Allan D. Struthers, Graham A. Hitman, Thomas Larsen, Faisel Khan, Rinkoo Dalan, Peter Marckmann, Stefan Pilz, Ilaria Barchetta, Ryan A. Harris, Miles D. Witham, Hans Stricker, Louise A. Beveridge, Gavin Dreyer, Carmine Zoccali, Nita G. Forouhi, Robert Clarke, Rajesh Khadgawat, Iain Bressendorff, Seth I. Sokol
Přispěvatelé: Forouhi, Nita [0000-0002-5041-248X], Apollo - University of Cambridge Repository, Lee Kong Chian School of Medicine (LKCMedicine)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Paricalcitol
Male
Treatment outcome
Physiology
vitamin D
030204 cardiovascular system & hematology
0302 clinical medicine
endothelial function
systematic review
Cardiovascular Disease
Medicine
030212 general & internal medicine
vitamin D vascular function therapy
Young adult
Vitamin D
Vascular Stiffness/drug effects
Cardiovascular Diseases/diagnosis
Systematic Review and Meta‐Analysis
Middle Aged
3. Good health
Treatment Outcome
Cardiovascular Diseases
Meta-analysis
paricalcitol
Female
Cardiology and Cardiovascular Medicine
Vascular function
medicine.drug
Adult
Endothelium
Vascular/drug effects

Adolescent
vascular function
03 medical and health sciences
Young Adult
Vascular Stiffness
Vitamin D and neurology
Humans
Vitamin D/adverse effects
Aged
Vitamin d supplementation
business.industry
Hemodynamics
Vitamin D Deficiency
Increased risk
Hemodynamics/drug effects
Endothelial Function
Vitamin D Deficiency/diagnosis
Dietary Supplements
Systematic review
Endothelium
Vascular

Dietary Supplements/adverse effects
business
Biomarkers/blood
Biomarkers
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Beveridge, L A, Khan, F, Struthers, A D, Armitage, J, Barchetta, I, Bressendorff, I, Cavallo, M G, Clarke, R, Dalan, R, Dreyer, G, Gepner, A D, Forouhi, N G, Harris, R A, Hitman, G A, Larsen, T, Khadgawat, R, Marckmann, P, Mose, F H, Pilz, S, Scholze, A, Shargorodsky, M, Sokol, S I, Stricker, H, Zoccali, C & Witham, M D 2018, ' Effect of Vitamin D Supplementation on Markers of Vascular Function : A Systematic Review and Individual Participant Meta-Analysis ', Journal of the American Heart Association, vol. 7, no. 11, e008273 . https://doi.org/10.1161/JAHA.117.008273
Beveridge, L A, Khan, F, Struthers, A D, Armitage, J, Barchetta, I, Bressendorff, I, Cavallo, M G, Clarke, R, Dalan, R, Dreyer, G, Gepner, A D, Forouhi, N G, Harris, R A, Hitman, G A, Larsen, T, Khadgawat, R, Marckmann, P, Mose, F H, Pilz, S, Scholze, A, Shargorodsky, M, Sokol, S I, Stricker, H, Zoccali, C & Witham, M D 2018, ' Effect of vitamin D supplementation on markers of vascular function : A systematic review and individual participant meta-analysis ', Journal of the American Heart Association, vol. 7, no. 11, e008273 . https://doi.org/10.1161/JAHA.117.008273
DOI: 10.1161/jaha.117.008273
Popis: Background: Low 25‐hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear.Methods and Results: We conducted a systematic review and individual participant meta‐analysis to examine the effect of vitamin D supplementation on flow‐mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo‐controlled randomized trials of at least 4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial‐level meta‐analysis was performed using random‐effects models; individual participant meta‐analyses used a 2‐stage analytic strategy, examining effects in prespecified subgroups. 31 trials (2751 participants) were included; 29 trials (2641 participants) contributed data to trial‐level meta‐analysis, and 24 trials (2051 participants) contributed to individual‐participant analyses. Vitamin D3 daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to 12 months. Trial‐level meta‐analysis showed no significant effect of supplementation on macrovascular measures (flow‐mediated dilatation, 0.37% [95% confidence interval, −0.23 to 0.97]; carotid‐femoral pulse wave velocity, 0.00 m/s [95% confidence interval, −0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial‐level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues.Conclusions: Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis. Beveridge LA Beveridge, LA Author Khan F Khan, F Author 0000-0002-9889-0229 Struthers AD Struthers, AD Author
Databáze: OpenAIRE