Vitamin-A Reversal of Abnormal Dark Adaptation in Cirrhosis
| Autor: | Frank Rees Smith, Edwin V. Oaks, Robert M. Russell, Stanley A. Morrison, Elizabeth A. Carney |
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| Rok vydání: | 1978 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Cirrhosis genetic structures Retinol transport Dark Adaptation Tretinoin chemistry.chemical_compound Liver Function Tests Liver Cirrhosis Alcoholic Internal medicine Internal Medicine Humans Prealbumin Medicine Vitamin A biology medicine.diagnostic_test business.industry Retinol Esters General Medicine Middle Aged medicine.disease Retinol-Binding Proteins Zinc Transthyretin Retinol binding protein Endocrinology chemistry biology.protein business Liver function tests Retinol-Binding Proteins Plasma medicine.drug |
| Zdroj: | Annals of Internal Medicine. 88:622 |
| ISSN: | 0003-4819 |
| Popis: | Of 26 patients hospitalized with mild to moderate alcohol-associated cirrhosis, 14 had dark-adaptation abnormalities consistent with marginal vitamin-A status. The response of dark adaptation and the plasma retinol transport proteins, retinol-binding protein and prealbumin, was studied in 12 of these patients after daily oral vitamin-A supplements of 3300 microgram. Vitamin-A supplementation was associated with significant (p less than 0.05-0.005) improvement in dark adaptation and increased plasma concentrations of retinyl esters, retinol, and retinol-binding protein. Thus in patients with cirrhosis and marginal vitamin-A status, supplemental vitamin-A therapy appears to stimulate retinol-binding protein release from the liver. This enhancement of plasma retinol transport and delivery of retinol to peripheral tissues such as the retina is one of several factors that may serve to optimize vitamin-A nutritional status in patients with cirrhosis. |
| Databáze: | OpenAIRE |
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