Dose-Dependent Effect of Bacillus sp. Metabolites from Permafrost on Lymphocyte Differentiation in the Thymus
| Autor: | L. F. Kalenova, A. S. Bazhin, S. A. Petrov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell Extracts Male medicine.medical_treatment T cell T-Lymphocytes Intraperitoneal injection Permafrost chemical and pharmacologic phenomena Bacillus Thymus Gland General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice 0302 clinical medicine medicine Animals IL-2 receptor biology Dose-Response Relationship Drug Chemistry T-cell receptor CD44 Lymphocyte differentiation hemic and immune systems Cell Differentiation General Medicine Molecular biology Hematopoiesis Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure biology.protein Metabolome Mice Inbred CBA Bone marrow 030217 neurology & neurosurgery CD8 |
| Zdroj: | Bulletin of experimental biology and medicine. 169(1) |
| ISSN: | 1573-8221 |
| Popis: | We studied the effect of a single intraperitoneal injection of metabolites from Bacillus sp. M3 strain isolated from permafrost (from 5×103 to 50×103 microbial bodies) on differentiation of T cells in the thymus of F1(CBA/Black-6) mice. On day 21 after the injection of metabolites, a dose-dependent decrease in the level of CD34+CD44+ and an increase in the number of CD34+CD44-, CD25-TCR+, CD25+TCR+max, CD4+CD8-, CD4-CD8+, and CD44+TCR+ lymphocytes were observed in the thymus. The increase in thymus level of mature (CD25+TCR+max) and migration-ready (CD44+TCR+) T cells in combination with a moderate decrease in the level of T cell precursors entering the thymus from the bone marrow (CD34+CD44+) can indicate a modulating influence of Bacillus sp. metabolites on functional activity of the thymus aimed at maintenance of the T cell balance in the body. |
| Databáze: | OpenAIRE |
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