BK polyomavirus in Iranian patients with papillary thyroid cancer: Is it a major future challenge?

Autor: Rahil Tarharoudi, Soyar Sari, Fatemeh Sakhaee, Farzam Vaziri, Fatemeh Rahimi Jamnani, Seyed Davar Siadat, Abolfazl Fateh
Rok vydání: 2022
Předmět:
Zdroj: Journal of Medical Virology. 94:6023-6027
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.28047
Popis: BK polyomavirus (BKPyV) is a well-known cause of nephropathy in renal transplant recipients. It has recently received much attention from researchers as a major predisposing factor for various cancers. This study aimed to investigate how BKPyV affected the advancement of papillary thyroid carcinoma (PTC). A total of 1057 samples were tested for BKPyV DNA and RNA, comprising 645 paraffin-embedded PTC biopsy samples (PEBS), 412 fresh biopsy samples (FBS), and 1057 adjacent noncancerous samples. The BKPyV DNA was found in 511 (48.3%) of the specimens, including 347 (84.2%) FBS and 164 (25.4%) PEBS. The mean BKPyV copy number was significantly lower in patients with PEBS (0.5 × 10
Databáze: OpenAIRE
Externí odkaz: