Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy)
| Autor: | Gregor K. Wenning, François Tison, Zoe Puschban, Christoph Scherfler, Werner Poewe, Elsa Diguet, Nadia Stefanova, T. Sather |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Dopamine and cAMP-Regulated Phosphoprotein 32 Movement Neurotoxins Striatonigral Degeneration Striatum Pharmacology Lesion chemistry.chemical_compound Parkinsonian Disorders medicine Animals Rats Wistar Amyotrophic lateral sclerosis Oxidopamine Medial forebrain bundle Biological Psychiatry Neurons Riluzole business.industry Parkinsonism Medial Forebrain Bundle Multiple System Atrophy Quinolinic Acid medicine.disease Denervation Corpus Striatum Rats Substantia Nigra Disease Models Animal Psychiatry and Mental health Neuroprotective Agents Treatment Outcome nervous system Neurology chemistry Nerve Degeneration Neurology (clinical) medicine.symptom business Excitatory Amino Acid Antagonists Neuroscience Biomarkers medicine.drug |
| Zdroj: | Journal of Neural Transmission. 112:1025-1033 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | We investigated neuroprotective effects of riluzole, an anti-glutamatergic agent that is FDA approved for disease-modifying therapy in amyotrophic lateral sclerosis (ALS), in an established double lesion rat model of striatonigral degeneration (SND), the neuropathological substrate of parkinsonism associated with MSA (MSA-P). Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum. Assessment of motor behaviour using a flex field system showed a significant reduction of motor disturbance in animals with striatonigral lesions treated with riluzole compared to lesioned but untreated animals (P |
| Databáze: | OpenAIRE |
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