Increased platelet reactivity in Klinefelter men: something new to consider
| Autor: | Giovanni Lupoli, Antonio Cittadini, Giacomo Accardo, Daniela Esposito, Dario Giugliano, Daniela Pasquali, M. N. D. Di Minno, A. Di Minno |
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| Přispěvatelé: | Di Minno, M. N. D, Esposito, Daniela, Di Minno, A, Accardo, G, Lupoli, G, Cittadini, A, Giugliano, Dario, Pasquali, Daniela, DI MINNO, Matteo, Esposito, D., Di Minno, A., Accardo, Giacomo, Lupoli, Giovanni, Cittadini, Antonio, Giugliano, D., Pasquali, D. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Blood Platelets
cardiovascular risk Adult Male medicine.medical_specialty Platelet Aggregation Urology Endocrinology Diabetes and Metabolism Stimulation platelet hyper-reactivity Dinoprost chemistry.chemical_compound Endocrinology Klinefelter Syndrome Risk Factors Internal medicine Cardiovascular Disease Medicine Humans Platelet Platelet activation Testosterone Cross-Sectional Studie Creatinine Estradiol business.industry Risk Factor medicine.disease Platelet Activation Thromboxane B2 Cross-Sectional Studies Reproductive Medicine chemistry Cardiovascular Diseases testosterone Blood Platelet Arachidonic acid Klinefelter syndrome business Human |
| Zdroj: | Europe PubMed Central |
| Popis: | Patients with Klinefelter syndrome (KS) exhibit an increased cardiovascular risk, but underlying mechanisms are largely unknown. The present cross-sectional study has been conducted to evaluate platelet reactivity and the expression of platelet activation markers (8-iso-prostaglandin F2α[8-iso-PGF2α] and 11-dehydro-thromboxane-B₂[11-dehydro-TXB2]) in KS patients and healthy controls. Twenty-three consecutive KS patients under testosterone replacement therapy have been included as case group and 46 age-matched healthy males recruited among hospital staff served as controls. Light transmission aggregometry was performed in both cases and controls and maximal platelet aggregation (max-A%) was defined as maximal light transmittance reached within 5min after the addition of 0.2 or 0.4mm arachidonic acid (AA). A≥50% irreversible light transmittance (LT-50%) following platelet stimulation defined an adequate platelet aggregation and AC-50% was defined as the minimal agonist concentration needed to achieve LT-50%. The AC-50% was 0.26mm AA for KS and 0.36mm for controls (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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