Atomoxetine monotherapy compared with combination therapy for the treatment of ADHD: a retrospective chart review study
| Autor: | Dustin D. Ruff, Brad D Berman, Donna S Holland, Craig L. Donnelly, Elias H Sarkis, Andre B Araujo, Kory Schuh, Adelaide S. Robb, Janet M Barnes, David B. Clemow, Oren W Mason |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Combination therapy Atomoxetine Hydrochloride Internal medicine mental disorders medicine Humans Pharmacology (medical) Child Adverse effect Retrospective Studies Adrenergic Uptake Inhibitors business.industry General Neuroscience Atomoxetine Confounding Discontinuation Treatment Outcome Attention Deficit Disorder with Hyperactivity Cohort Propensity score matching Drug Therapy Combination Observational study Neurology (clinical) business Clinical psychology medicine.drug |
| Zdroj: | Expert Review of Neurotherapeutics. 15:1353-1366 |
| ISSN: | 1744-8360 1473-7175 |
| Popis: | To analyze Clinical Global Impression-Severity (CGI-S) in ADHD patients treated with atomoxetine (ATX) monotherapy versus ATX combination therapy with another ADHD-indicated medication.This was a 2-site retrospective observational chart review study of child and adult ADHD patients, not necessarily treatment naïve, but treated ≥50 days post baseline with an endpoint assessment. To adjust for measured confounders, monotherapy (n = 77) versus combination (n = 108) cohort comparisons were performed using propensity score stratification and adjusted ANCOVA.There were no significant baseline cohort differences after propensity stratification. CGI-S scores after a mean 264 days of treatment were not statistically significantly different between cohorts, with no cohort differences observed in any assessed symptom subcategory. The cohorts were similar in discontinuation due to any reason, adverse event, and lack of efficacy.ATX combination therapy showed no evidence of additional benefit over ATX monotherapy in the treatment of ADHD in a community-based setting. |
| Databáze: | OpenAIRE |
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