Effect of HLA-A and HLA-B matching on survival of grafts and recipients after renal transplantation
| Autor: | van Rood Jj, Lansbergen Q, Selwood N, D'Amaro J, Cohen B, Wing A, Guido G. Persijn |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Human leukocyte antigen Gastroenterology Postoperative Complications Antigen Actuarial Analysis HLA Antigens Internal medicine Medicine Humans Transplantation Homologous Dialysis Kidney business.industry Histocompatibility Testing Graft Survival General Medicine Kidney Transplantation HLA-B HLA-A Surgery Transplantation medicine.anatomical_structure HLA-B Antigens business Donor kidney Follow-Up Studies |
| Zdroj: | The New England journal of medicine. 307(15) |
| ISSN: | 0028-4793 |
| Popis: | Data on the effect of HLA-A and HLA-B matching between unrelated donors and recipients focus mainly on graft survival. After linking the follow-up data of the European Dialysis and Transplant Association and those of the Eurotransplant Foundation, the effect of HLA-A and HLA-B matching on recipient survival could be studied. Recipients of well-matched kidneys — i.e., without mismatches for the HLA-A and B antigens — had 51 per cent graft survival at five years, whereas recipients of grafts mismatched for four antigens had 32 per cent graft survival at five years. The overall P value between the five different mismatch classes was 0.0005. Patient survival at five years was 72 per cent in recipients of a kidney without HLA-A and B mismatches and 54 per cent in recipients of a completely mismatched donor kidney (overall, P = 0.001). These results suggest that matching for the HLA antigens has a beneficial long-term effect not only on renal-allograft survival but also on patient survival. (N Engl J M... |
| Databáze: | OpenAIRE |
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