Segmental Atrophy of Explanted Livers in Biliary Atresia: Pathological Data From 63 Cases of Failed Portoenterostomy
| Autor: | Toshihiro Muraji, Takako Yoshioka, Yutaka Kanamori, Seisuke Sakamoto, Akihiro Fujino, Kenji Santo, Mureo Kasahara, Akinari Fukuda, Toshihiko Shibata, Masaki Horiike, Noriyuki Nakano |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Portoenterostomy Hepatic Liver transplantation Severity of Illness Index Gastroenterology End Stage Liver Disease 03 medical and health sciences Liver disease 0302 clinical medicine Atrophy Cholestasis Biliary Atresia Biliary atresia Fibrosis 030225 pediatrics Internal medicine Biopsy medicine Humans Child Pathological medicine.diagnostic_test business.industry Infant medicine.disease Child Preschool Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 72:88-94 |
| ISSN: | 1536-4801 0277-2116 |
| Popis: | OBJECTIVES Atrophy of the left lateral segment (LLS) is often encountered in liver transplantation (LT) for biliary atresia (BA). To clarify the meaning of the heterogeneous atrophy, we compared the pathological characteristics of the LLS with the right posterior segment (RPS) of BA livers obtained during LT. METHODS Among the 116 patients with BA who underwent LT at our hospital between 2014 and 2018, 63 patients with persistent cholestasis after the Kasai portoenterostomy (KP) were selected. Three pathologists evaluated tissues from the LLS and RPS for 5 pathological parameters. Positive areas in whole-slide image observed as portal inflammation, fibrosis, cholestasis, and ductular reaction, were analyzed with automated image quantitation. Moreover, we examined the relationship between the pathological score and the Pediatric End-stage Liver Disease (PELD) score. RESULTS The median age at LT was 7 months (range 4-26 months). Inflammation and fibrosis were significantly greater in the LLS than in the RPS (P |
| Databáze: | OpenAIRE |
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