Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes

Autor: Fátima Carneiro, Francesco Limarzi, Irene Gullo, Alessandro Vanoli, Luca Mastracci, Matteo Fassan, Luca Saragoni, Federica Grillo, Jacopo Ferro, Paola Parente
Přispěvatelé: Instituto de Investigação e Inovação em Saúde
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Oncology
medicine.medical_specialty
gastric adenocarcinoma
gastric cancer
gastric dysplasia
hereditary diffuse gastric cancer (HDGC)
hereditary gastric cancer syndromes
Gastric dysplasia
Review
Stomach Neoplasms / diagnosis
Hereditary gastric cancer syndromes
Adenocarcinoma
Malignancy
Neoplastic Syndromes
Hereditary / genetics
Pathology and Forensic Medicine
Neoplastic Syndromes
Hereditary
Stomach Neoplasms
Internal medicine
Hereditary diffuse gastric cancer (HDGC)
medicine
Genetic predisposition
Neoplastic Syndromes
Hereditary / pathology
Stomach Neoplasms / epidemiology
Humans
Genetic Predisposition to Disease
Stomach Neoplasms / genetics
Stage (cooking)
Gastric adenocarcinoma
business.industry
Neoplastic Syndromes
Hereditary / epidemiology
Stomach
Incidence
Cancer susceptibility
Cancer
Pathology Report
medicine.disease
Prognosis
Gastric Dysplasia
medicine.anatomical_structure
Neoplastic Syndromes
Hereditary / diagnosis
Stomach / pathology
business
Gastric cancer
Stomach Neoplasms / pathology
Precancerous Conditions
Zdroj: Pathologica
Popis: Summary Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently diagnosed malignancy and the third leading cause of cancer related death. Gastric carcinogenesis is a multistep and multifactorial process and is the result of the complex interplay between genetic susceptibility and environmental factors. The identification of predisposing conditions and of precancerous lesions is the basis for screening programs and early stage treatment. Furthermore, although most gastric cancers are sporadic, familial clustering is observed in up to 10% of patients. Among them, hereditary cases, related to known cancer susceptibility syndromes and/or genetic causes are thought to account for 1-3% of all gastric cancers. The pathology report of gastric resections specimens therefore requires a standardized approach as well as in depth knowledge of prognostic and treatment associated factors.
Databáze: OpenAIRE
Externí odkaz: