Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
| Autor: | Marc Schneeberger, Amandine Everard, Alicia G. Gómez-Valadés, Sara Ramírez, Marc Claret, Ramon Gomis, Sébastien Matamoros, Nathalie M. Delzenne, Patrice D. Cani |
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| Přispěvatelé: | UCL - SSS/LDRI - Louvain Drug Research Institute, Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Time Factors medicine.medical_treatment Adipose tissue Gene Expression Microbiologia Gut flora 0302 clinical medicine RNA Ribosomal 16S Homeostasis 2. Zero hunger 0303 health sciences Intestins Multidisciplinary Reverse Transcriptase Polymerase Chain Reaction Leptin Age Factors Intestines Adipose Tissue Host-Pathogen Interactions Obesitat medicine.symptom Akkermansia muciniphila medicine.medical_specialty Ratolins (Animals de laboratori) 030209 endocrinology & metabolism Inflammation Context (language use) Bilophila Biology Diet High-Fat Microbiology Article 03 medical and health sciences Metabolic Diseases Species Specificity Verrucomicrobia Internal medicine medicine Animals Obesity 030304 developmental biology Bacteria Insulin Lipid metabolism Adipose tissues biology.organism_classification Lipid Metabolism Bacterial Load Gastrointestinal Microbiome Gastrointestinal Tract Mice Inbred C57BL Teixit adipós Endocrinology Mice (Laboratory animals) |
| Zdroj: | Scientific Reports, Vol. 5, p. 16643 [1-14] (2015) Scientific Reports Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| Popis: | Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time. We found that Akkermansia muciniphila abundance was strongly and negatively affected by age and HFD feeding and to a lower extend Bilophila wadsworthia was the only taxa following an opposite trend. Different approaches, including multifactorial analysis, showed that these changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice. Thus, our data shows the existence of a link between gut Akkermansia muciniphila abundance and adipose tissue homeostasis on the onset of obesity, thus reinforcing the beneficial role of this bacterium on metabolism. |
| Databáze: | OpenAIRE |
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