Familial Cushing's syndrome due to nodular adrenocortical dysplasia. A putative receptor-antibody disease?
| Autor: | R. D. Gaag, Hemmo A. Drexhage, C. D. Kooyman, Louis Kater, F. J. H. Gmelig Meyling, H. J. Schuurman, D. Jolink, R. J. M. Croughs, F. Teding Van Berkhout |
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| Rok vydání: | 1986 |
| Předmět: |
Adrenal Cortex Diseases
Adult medicine.medical_specialty Pathology Adolescent Endocrinology Diabetes and Metabolism Immunoglobulins Lymphocytic Infiltrate Pathogenesis Cushing syndrome Endocrinology Immunopathology Internal medicine Adrenal Glands medicine Humans Cushing Syndrome biology Adrenal cortex business.industry Adrenal Scintigraphy Adrenalectomy medicine.disease medicine.anatomical_structure Dysplasia biology.protein Female Pituitary-Adrenal Function Tests Antibody business |
| Zdroj: | Clinical endocrinology. 24(3) |
| ISSN: | 0300-0664 |
| Popis: | SUMMARY Two sisters aged 13 and 19 years suffering from familial Cushing's syndrome due to nodular adrenocortical dysplasia are described. Pituitary adrenocortical function tests indicated the presence of adrenal autonomy. Adrenal scintigraphy showed bilateral symmetrical uptake indicating the bilateral character of the autonomous process. Complete adrenalectomy was performed in both girls. The adrenals were of about normal weight showing numerous dark brown pigmented nodules and small perivascular lymphocytic infiltrates. Serum immunoglobulin preparations obtained from both girls stimulated adrenocortical cell growth in a cytochemical bioassay system. It is proposed that circulating growth factors may be involved in the pathogenesis of the disease. |
| Databáze: | OpenAIRE |
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